Efficacy of rhPDGF as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal
About this trial
This is an interventional treatment trial for Periodontal Diseases focused on measuring rhPDGF, Growth factors, Periodontal regeneration
Eligibility Criteria
Inclusion Criteria: Patients with a diagnosis of periodontitis stage III or IV (grades A to C), non-smokers or former smokers who quit at least 1 year ago, and had not received any periodontal treatment in the 3 months prior to recruitment; Presence of at least 1 Infrabony defect (PPD ≥ 5 mm with infrabony defect depth of ≥3mm at screening radiograph); One and two wall infrabony defects at screening radiograph and periodontal charting. Signed informed consent. Exclusion Criteria: Presence of uncontrolled systemic diseases that could affect treatment outcomes such as diabetes mellitus with an HbA1C>7%, rheumatoid arthritis or any form of immunosuppression; Subjects requiring antibiotic prophylaxis; 3-wall infrabony defects; Patients that had received systemic or local delivery of antibiotic therapy 6 weeks before enrollment; Presence of furcation defect; Chronic intake of NSAIDs or steroids, currently; Patients undergoing orthodontic treatment, having removable prosthetic appliances, pregnancy, tumors of the oral cavity or the presence of any psychiatric condition that could affect participation.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
SRP+rhPDGF
SRP+ collagen sponge
SRP alone
After SRP the infrabony defect will be filled with a collagen sponge soaked in rhPDGF.
After SRP the infrabony defect will be filled with a collagen sponge soaked in saline solution.
SRP alone will be performed.