Determining the Lipid Lowering Effect of Fenugreek Seed Tea
Hyperlipidemias
About this trial
This is an interventional other trial for Hyperlipidemias focused on measuring Fenugreek, Hyperlipidaemia
Eligibility Criteria
Inclusion Criteria: Both male and female patients aged between 18-70 years old Patients with hyperlipidaemia (plasma triglyceride level between 1.7 - 4.5mmol/l) not on any lipid-lowering treatment or on a stable lipid-lowering treatment (last six months) but still have confirmation of high triglycerides within the range required for study Willing not to change any dietary behaviours, with the exception of participating in the intervention, over the course of the study Participants can be recruited onto the study if they are involved in other research studies, but this will depend on the study type and the decision will be made by the Chief Investigator and/or Principal Investigator. Exclusion Criteria: Patients with type 1 or type 2 diabetes, asthma, allergic reactions, respiratory, kidney, and neurological diseases, psychiatric disorders or pre-existing CVD Living in a residential or nursing care home Taking high dose nutritional supplements above the dietary reference values Consumption of alcohol above current recommended levels (14 units per week), pregnancy or lactation Inability to provide informed consent Any other problem which would prevent adherence to fenugreek intervention
Sites / Locations
- Centre for Public Health, Institute of Clinical Sciences ARecruiting
- Queen's University BelfastRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Fenugreek Seed Tea
Black Tea
Fenugreek seeds will be delivered at a dose of 5g/day, drunk as a tea (2.5g/per tea bag), p.o. twice a day at a 12-hour interval) for 8 weeks (56 days). The tea bags will be brewed in a cup (200ml) of boiled hot water for 10 minutes before drinking. This will be self-administered by the subjects, twice a day at a 12-hour interval. The rationale for choosing the dose and intervention time course were based on the previous studies where metabolic effects have been detected. Literature reports from 12 human studies on diabetic and pre-diabetic subjects gave doses of fenugreek seed ranging from 1 to 100g/day, with the median treatment dose being 6.3g/day, to the participants; the intervention time course ranged from 1 week to 3 years, with the median treatment time being 60 days. The dose and duration in this study was designed as being similar to these studies where metabolic effects have been detected and where participant burden will not be too onerous.
Control group: A control black tea (2.5g/bag), self-administered by the subjects, twice in a day at a 12-hour interval. Black tea is a type of fermented tea that has been found to possess much less cardioprotective and lipid profile improving effect compared to green tea due to the different manufacture process. Consumption of black tea has been found not associated with a reduced risk of coronary heart disease in the United Kingdom. Therefore, we propose to use black tea as control tea for this study.