Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians in Heart Failure (MAPLE-CHF)
Heart Failure
About this trial
This is an interventional screening trial for Heart Failure focused on measuring Heart failure screening, natriuretic peptides, artificial intelligence echocardiography
Eligibility Criteria
Inclusion Criteria: Male or female > 40 years of age Informed consent At least two additional risk factors for Heart Failure (HF): Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis or an epicardial coronary artery (50% left main stem or >70% left anterior descending, circumflex or right coronary artery)). Diabetes type 1 or 2. Persistent or permanent atrial fibrillation. Previous ischemic or embolic stroke. Peripheral artery disease (previous surgical or percutaneous revascularization or documented stenosis >50% of major peripheral arterial vessel. Chronic kidney disease (defined as an estimated glomerular filtration rate (eGFR)<60 milliliters per minute (mL/min)/1.73m2 or eGFR 60-90 mL/min/1.73m2 and urine albumin-creatinine ration (UACR) >300mg/g). Regular loop diuretic use for >30 days within 12 months prior to consent. Chronic obstructive pulmonary disease (COPD) evidenced by one of the following: Pulmonary Function Test (PFT) showing airway obstruction, diagnosis of respiratory physician, CT scan reporting presence of emphysema, or treatment with national guidance advocated COPD therapy. Exclusion Criteria: Inability to give informed consent (e.g. due to significant cognitive impairment). Previous diagnosis of heart failure. This is any diagnosis of heart failure with any ejection fraction of any cause. Renal replacement therapy. Anyone who, in the investigator's opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period.
Sites / Locations
- Vancouver General Hospital
- Montreal Heart Institute
- University of Sherbrooke
Arms of the Study
Arm 1
Arm 2
Active Comparator
No Intervention
Investigational arm guided by NT-proBNP result
Routine care arm
NT-proBNP drawn and if level elevated (>125 pg/ml) a study visit with artificial intelligence (AI) echocardiogram, electrocardiogram (ECG), and heart failure (HF) focused examination conducted
Participants will be remotely monitored for number of heart failure events