Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection

Inclusion Criteria: Undergoing their first in vitro fertilization (IVF) cycle Electing single embryo transfer Electing preimplantation genetic testing for aneuploidy (PGT-A) of their embryos Female partners age <42 years old at start of vaginal oocyte retrieval cycle, but >18 years old. Normal ovarian reserve: Antimullerian hormone level (AMH) ≥ 1.2 ng/mL Antral follicle count (AFC) ≥ 8 At least 4 mature oocytes (M2s) retrieved at the VOR procedure in order to randomize At least 1 immature oocyteretrieved at the VOR procedure to perform ZP binding co-incubation procedure Intention to transfer the morphological best quality, euploid, embryo at the frozen embryo transfer procedure Exclusion Criteria: Contraindication to IVF Clinical indication for preimplantation genetic testing (i.e., screening for single gene disorder, chromosomal translocation, or any other disorders requiring a more detailed embryo genetic analysis) Male partner with azoospermia or oligozoospermia (<100,000 total motile spermatozoa) Male partner with Y-chromosome microdeletion Male partner with any Karyotype other than 46,XY Male partner requiring surgically obtained sperm either via testicular or epididymal retrieval procedures Uncorrected hydrosalpinges that communicate with the endometrial cavity Endometrial Insufficiency, as defined by a prior cycle with maximal endometrial thickness <6mm,), or persistent endometrial fluid Donor oocyte cycles Gestational carriers