Transmagnetic Stimulation Pilot in Primary Progressive Aphasia (TMS in PPA)
Primary Progressive Aphasia
About this trial
This is an interventional treatment trial for Primary Progressive Aphasia focused on measuring transmagnetic stimulation, functional MRI guided Theta Burst Stimulation
Eligibility Criteria
Inclusion Criteria: Established diagnosis of NFV-PPA and SV-PPA based on criteria (Gorno-Tempini et al., 2011) Prior brain imaging performed Mini Mental Status Exam (MMSE)>10 Subjects are between 40-90 years of age Exclusion Criteria: Non-FTD dementia including, but not limited to Alzheimer's, disease, Lewy body dementia, frontotemporal dementia, vascular dementia, Jakob-Creutzfeldt disease, etc. Inability to tolerate rs-fMRI Contraindication of rs-fMRI due to implants or metal Seizure disorder
Sites / Locations
- HealthPartners Neuroscience Center
Arms of the Study
Arm 1
Experimental
Intermittent theta burst stimulation
All subjects will receive treatment with intermittent theta burst stimulation (iTBS). There will be a total of 5 treatments over a 2-week period. All subjects will receive iTBS to the right TGd region. TBS treatment will also be provided for two additional sites within the large-scale brain networks (LSBNs) that is found to contain the greatest number of connectivity anomalies. Total participation will be 8-10 weeks.