Remote Ischemic Conditioning in Adult Moyamoya Disease Patients
Moyamoya Disease, Remote Ischemic Conditioning
About this trial
This is an interventional treatment trial for Moyamoya Disease
Eligibility Criteria
Inclusion Criteria: Patients aged from 18 to 65 years old; Subjects all performed digital subtraction angiography (DSA) and diagnosed with MMD accroding to the criteria recommended by the Research Committee on MMD (Spontaneous Occlusion of the Circle of Wills) of the Ministry of Health and Welfare of Japan in 201211. Modified Rankin Scale (mRS) score<4; Informed consent obtained from the patient or legally authorized representative. Exclusion Criteria: Subjects suffered from acute ischemic or hemorrhagic stroke within 3 months; Severe hepatic or renal dysfunction; Severe cardiac disease; Severe hemostatic disorder or severe coagulation dysfunction; Serious, advanced, or terminal illnesses with anticipated life expectancy of less than one year; Patients with moyamoya syndrome caused by autoimmune disease, Down syndrome, neurofibromatosis, leptospiral infection, or previous skull-base radiation therapy;
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
RIC group
Control group
Patients in RIC group and control group will achieve RIC intervention and sham RIC intervention three times daily from 5 days before operation and 7 days post operation
Patients in control group, bilateral upper arm cuffs were inflated to a pressure of 60 mm Hg for 5 minutes, followed by 5 minutes of relaxation of the cuffs