The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography (PASS)
Radial Artery Spasm
About this trial
This is an interventional prevention trial for Radial Artery Spasm focused on measuring Radial artery spasm, Papaverine, Cerebral angiography
Eligibility Criteria
Inclusion Criteria: All patients scheduled for cerebral angiography will be eligible for screening. Participant is willing and is able to give informed consent for participating in the trial. Male or Female, aged 18 years or above. Exclusion Criteria: Any patient with negative modified Allen test Altered liver function atrioventricular heart block III degree Suspected or confirmed cerebral hemorrhage patients Hemodynamic Instability : systolic pressure < 100 mmHg, heart rate > 100 bpm, tachycardia uncontrollable. Patients with cerebral edema and increased intracranial pressure within 24 hours to 2 weeks after stroke Coronary artery bypass grafting(CABG) operation history and whose right radial artery is missing as a "bridge vessel" Severe skin musculoskeletal malformation of forearm or failure to complete radial artery puncture and sheath placement for other reasons Hypersensitivity or contraindication to papaverine Hypersensitivity or contraindication to nitroglycerine Glaucomatous patients Parkinson's disease patients Women who are suspected or known to be pregnant or breastfeeding
Sites / Locations
- Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Papaverine
Placebo
Slowly inject 10ml of papaverine hydrochloride solution (30mg/10ml) through the successfully implanted radial artery sheath, and continuously drip papaverine hydrochloride solution (60mg/500ml, 4ml/min) through the artery sheath during the operation. The compatible solutions are normal saline(0.9%);
After inserting the radial artery sheath, slowly inject 10ml normal saline(0.9%) through the artery sheath, and continuously drip normal saline(0.9%, 500ml, 4ml/min) through the artery sheath during the operation.