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Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.

Primary Purpose

Hepatocellular Carcinoma

Status
Recruiting
Phase
Phase 3
Locations
China
Study Type
Interventional
Intervention
Anlotinib hydrochloride capsules, Penpulimab injection
Anlotinib hydrochloride capsules -matching placebo, Penpulimab injection -matching placebo
Sponsored by
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Hepatocellular Carcinoma

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Age: 18-75 years old; Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 1; Predicted survival ≥12 weeks. Subjects with hepatocellular carcinoma (HCC) confirmed by histopathology or cytology or who meet the diagnostic criteria for Primary Liver Cancer 2022 or the American Association for the Study of Hepatology (AASLD) hepatocellular carcinoma. Subjects who received radical excision or ablation (Radio Frequency Ablation (RFA) or Microwave Ablation (MWA) only) within 4 to 12 weeks prior to randomization (multiple modalities or combined or multiple treatments are not acceptable). No major vena portae 3 (Vp3) or vena portae 4 (Vp4) in the portal vein or any level of vascular invasion in the hepatic vein or inferior vena cava. No extrahepatic metastasis. High risk factors for recurrence after radical resection or complete ablation. Complete recovery from surgical resection or ablation within 4 weeks before randomization. Exclusion Criteria: Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC histology. Evidence of residual, recurrent, or metastatic disease at randomization. More than one surgical treatment for hepatocellular carcinoma; Received more than 1 prophylactic Transcatheter Arterial Chemoembolization (TACE) treatment after surgery; or received Hepatic Artery Infusion Chemotherapy (HAIC) therapy after surgery. Previous use of antiangiogenic drugs or PD-1, Programmed Cell Death-Ligand 1 (PD-L1) and other related immunotherapy drugs or systemic chemotherapy drugs.

Sites / Locations

  • The First Affiliated Hospital of Bengbu Medical CollegeRecruiting
  • Anhui Provincial HospitalRecruiting
  • The First Affiliated Hospital of Anhui Medical University
  • Peking Union Medical College HospitalRecruiting
  • Cancer Hospital Chinese Academy of Medical SciencesRecruiting
  • Peking University People's HospitalRecruiting
  • Beijing Friendship hospital of Capital Medical UniversityRecruiting
  • Beijing YouAn Hospital,Capital Medical UniversityRecruiting
  • Chongqing University Cancer Hospital
  • Chongqing University Three Gorges Hospital
  • Mengchao Hepatobiliary Hospital of Fujian MedicalRecruiting
  • Fujian Cancer HospitalRecruiting
  • Gansu Provincial Cancer HospitalRecruiting
  • Lanzhou University First Hospital
  • Lanzhou University Second Hospital
  • Gansu Provincial HospitalRecruiting
  • Guangdong People's Hospital
  • Zhujiang Hospital of Southern Medical UniversityRecruiting
  • The Third Affiliated Hospital of Sun Yat-sen UniversityRecruiting
  • Guangxi Medical University Affiliated Tumor Hospital
  • Guizhou Provincial People'S HospitalRecruiting
  • The Affiliated Cancer Hospital of Guizhou Medical University
  • Affiliated Hospital Of Zunyi Medical UniversityRecruiting
  • Hainan Provincial People's HospitalRecruiting
  • The Second Affiliated Hospital of Hainan Medical UniversityRecruiting
  • Affiliated Cancer Hospital of Harbin Medical UniversityRecruiting
  • The First Affiliated Hospital of Henan University of Science and TechnologyRecruiting
  • The First Affiliated Hospital of Zhengzhou UniversityRecruiting
  • Henan Cancer Hospital
  • Hunan Cancer Hospital
  • Hunan Provincial People's Hospital
  • The Third Xiang Ya Hospital of Central South UniversityRecruiting
  • Xiangya Hospital of Central South University
  • Chifeng Municipal HospitalRecruiting
  • The First People's Hospital of ChangzhouRecruiting
  • Jiangsu Province People's HospitalRecruiting
  • Affiliated Hospital of Nantong UniversityRecruiting
  • Nantong Tumor Hospital
  • Ganzhou People's HospitalRecruiting
  • The Second Affiliated Hospital of Nanchang UniversityRecruiting
  • Jilin Cancer Hospital
  • The Second Hospital of Dalian Medical UniversityRecruiting
  • The First Affiliated Hospital of Jinzhou Medical UniversityRecruiting
  • Shengjing Hospital of China Medical University
  • The Sixth People's Hospital of Shen YangRecruiting
  • Liaoning Cancer Hospital
  • Binzhou Medical University HospitalRecruiting
  • Shandong Cancer Hospital
  • The First Affiliated Hospital of Naval Medical UniversityRecruiting
  • Third Affiliated Hospital of Naval Medical UniversityRecruiting
  • Baoji Central HospitalRecruiting
  • Heping Hospital Affiliated to Changzhi Medical CollegeRecruiting
  • The Second Affiliated Hospital of Air Force Medical University
  • First Affiliated Hospital of Xian Jiaotong University
  • Xi'an International Medical Center HospitalRecruiting
  • West China Hospital of Sichuan UniversityRecruiting
  • Affiliated Hospital of Southwest Medical UniversityRecruiting
  • Affiliated Hospital Of North Sichuan Medical CollegeRecruiting
  • Tianjin Third Central HospitalRecruiting
  • Tianjin Medical University Cancer Institute & HospitalRecruiting
  • Tianjin Cancer Hospital Airport HospitalRecruiting
  • The First Affiliated Hospital of Xinjiang Medical University
  • Sir Run Run Shaw Hospital Zhetiang University School of MedicineRecruiting
  • Ningbo Medical Center Lihuili HospitalRecruiting
  • Shaoxing People's HospitalRecruiting
  • Taizhou Hospital of Zhejiang ProvinceRecruiting
  • The First Affiliated Hospital of Wenzhou Medical UniversityRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Anlotinib hydrochloride capsules + Penpulimab injection

Anlotinib hydrochloride capsules -matching placebo+ Penpulimab injection -matching placebo

Arm Description

Anlotinib hydrochloride capsules + Penpulimab injection, 21 days as a treatment cycle.

Anlotinib hydrochloride capsules -matching placebo+ penpulimab injection -matching placebo, 21 days as a treatment cycle.

Outcomes

Primary Outcome Measures

Recurrence-free survival (RFS)
RFS assessed by the Blinded Independent Image Review Committee and the investigator is the time from randomization to the first local, regional recurrence or distant metastasis, or death from any cause, whichever occurred first.

Secondary Outcome Measures

Time to recurrence(TTR)
TTR assessed by the Blinded Independent Image Review Committee and the investigator is the time from randomization to the first local, regional recurrence or distant metastasis, whichever occurred first.
Time to extrahepatic metastasis or macrovascular invasion
Time to extrahepatic metastasis or macrovascular invasion as assessed by the investigator.
Overall survival (OS)
OS defined as the time from the date of randomization until the date of death due to any cause.
Objective response rate (ORR) after first recurrence
subjects with evaluable tumor lesion status who were cross-treated with Anlotinib hydrochloride capsules combined with Penpulimab injection developed complete response or partial response after a first HCC relapse as assessed by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1.

Full Information

First Posted
May 15, 2023
Last Updated
May 15, 2023
Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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1. Study Identification

Unique Protocol Identification Number
NCT05862337
Brief Title
Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.
Official Title
A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study of Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection in Patients With High Risk of Relapse After Radical Surgery or Ablation of Hepatocellular Carcinoma (HCC).
Study Type
Interventional

2. Study Status

Record Verification Date
July 2022
Overall Recruitment Status
Recruiting
Study Start Date
May 10, 2023 (Actual)
Primary Completion Date
August 2024 (Anticipated)
Study Completion Date
December 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
The primary objective of this study was to evaluate the efficacy of anlotinib hydrochloride capsules combined with penpulimab injection (test group) versus placebo (control group) for adjuvant therapy after radical surgery or ablation in HCC patients with high risk of recurrence by assessing recurrence-free survival (RFS).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hepatocellular Carcinoma

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
480 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Anlotinib hydrochloride capsules + Penpulimab injection
Arm Type
Experimental
Arm Description
Anlotinib hydrochloride capsules + Penpulimab injection, 21 days as a treatment cycle.
Arm Title
Anlotinib hydrochloride capsules -matching placebo+ Penpulimab injection -matching placebo
Arm Type
Placebo Comparator
Arm Description
Anlotinib hydrochloride capsules -matching placebo+ penpulimab injection -matching placebo, 21 days as a treatment cycle.
Intervention Type
Drug
Intervention Name(s)
Anlotinib hydrochloride capsules, Penpulimab injection
Intervention Description
Anlotinib hydrochloride capsules is a multitargeted receptor tyrosine kinase inhibitor. Penpulimab injection is a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1).
Intervention Type
Drug
Intervention Name(s)
Anlotinib hydrochloride capsules -matching placebo, Penpulimab injection -matching placebo
Intervention Description
placebo control, no active substance.
Primary Outcome Measure Information:
Title
Recurrence-free survival (RFS)
Description
RFS assessed by the Blinded Independent Image Review Committee and the investigator is the time from randomization to the first local, regional recurrence or distant metastasis, or death from any cause, whichever occurred first.
Time Frame
Baseline up to 3 years.
Secondary Outcome Measure Information:
Title
Time to recurrence(TTR)
Description
TTR assessed by the Blinded Independent Image Review Committee and the investigator is the time from randomization to the first local, regional recurrence or distant metastasis, whichever occurred first.
Time Frame
Baseline up to 3 years.
Title
Time to extrahepatic metastasis or macrovascular invasion
Description
Time to extrahepatic metastasis or macrovascular invasion as assessed by the investigator.
Time Frame
Baseline up to 3 years.
Title
Overall survival (OS)
Description
OS defined as the time from the date of randomization until the date of death due to any cause.
Time Frame
Baseline up to 3 years.
Title
Objective response rate (ORR) after first recurrence
Description
subjects with evaluable tumor lesion status who were cross-treated with Anlotinib hydrochloride capsules combined with Penpulimab injection developed complete response or partial response after a first HCC relapse as assessed by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1.
Time Frame
Baseline up to 3 years.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age: 18-75 years old; Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 1; Predicted survival ≥12 weeks. Subjects with hepatocellular carcinoma (HCC) confirmed by histopathology or cytology or who meet the diagnostic criteria for Primary Liver Cancer 2022 or the American Association for the Study of Hepatology (AASLD) hepatocellular carcinoma. Subjects who received radical excision or ablation (Radio Frequency Ablation (RFA) or Microwave Ablation (MWA) only) within 4 to 12 weeks prior to randomization (multiple modalities or combined or multiple treatments are not acceptable). No major vena portae 3 (Vp3) or vena portae 4 (Vp4) in the portal vein or any level of vascular invasion in the hepatic vein or inferior vena cava. No extrahepatic metastasis. High risk factors for recurrence after radical resection or complete ablation. Complete recovery from surgical resection or ablation within 4 weeks before randomization. Exclusion Criteria: Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC histology. Evidence of residual, recurrent, or metastatic disease at randomization. More than one surgical treatment for hepatocellular carcinoma; Received more than 1 prophylactic Transcatheter Arterial Chemoembolization (TACE) treatment after surgery; or received Hepatic Artery Infusion Chemotherapy (HAIC) therapy after surgery. Previous use of antiangiogenic drugs or PD-1, Programmed Cell Death-Ligand 1 (PD-L1) and other related immunotherapy drugs or systemic chemotherapy drugs.
Facility Information:
Facility Name
The First Affiliated Hospital of Bengbu Medical College
City
Bengbu
State/Province
Anhui
ZIP/Postal Code
233000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lu Zheng, Doctor
Phone
+86 13721179461
Email
luzhengdr@163.com
Facility Name
Anhui Provincial Hospital
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lianxin Liu, Doctor
Phone
+86 18096656677
Email
liulx@ustc.edu.cn
Facility Name
The First Affiliated Hospital of Anhui Medical University
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yufeng Gao, Doctor
Phone
+86 13956938032
Email
aygyf@126.com
Facility Name
Peking Union Medical College Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100005
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haitao Zhao, Doctor
Phone
+86 13901246374
Email
zhaoht@pumch.cn
Facility Name
Cancer Hospital Chinese Academy of Medical Sciences
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongguang Wang, Doctor
Phone
+86 13717659265
Email
wanghongguang301@163.com
Facility Name
Peking University People's Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100044
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lei Chen, Doctor
Phone
+86 13911995059
Email
chenlei@pkuph.edu.cn
Facility Name
Beijing Friendship hospital of Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100050
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhongtao Zhang, Doctor
Phone
+86 13801060364
Email
zhangzht@ccmu.edu.cn
Facility Name
Beijing YouAn Hospital,Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100069
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yonghong Zhang, Doctor
Phone
+86 13810108505
Facility Name
Chongqing University Cancer Hospital
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400030
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dewei Li, Doctor
Phone
+86 13618317772
Email
lidewei406@sina.com
Facility Name
Chongqing University Three Gorges Hospital
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
404199
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xuan An, Master
Phone
+86 13996835633
Email
57485971@qq.com
Facility Name
Mengchao Hepatobiliary Hospital of Fujian Medical
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350001
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haitao Li, Doctor
Phone
+86 18950242262
Email
lht45182@163.com
Facility Name
Fujian Cancer Hospital
City
Fuzhou
State/Province
Fujian
ZIP/Postal Code
350011
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jingfeng Liu, Doctor
Phone
+86 13905029580
Email
drjingfeng@126.com
Facility Name
Gansu Provincial Cancer Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yan Yang, Bachelor
Phone
+86 13639395521
Email
Yangyantd1992@163.com
Facility Name
Lanzhou University First Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lei Zhang, Doctor
Phone
+86 13993181644
Email
13993181644@139.com
Facility Name
Lanzhou University Second Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730030
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wence Zhou, Doctor
Phone
+86 13893699909
Email
Zhouwc129@163.com
Facility Name
Gansu Provincial Hospital
City
Lanzhou
State/Province
Gansu
ZIP/Postal Code
730700
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Minggang Zheng, Doctor
Phone
+86 13893260496
Email
zhengninggang0707@163.com
Facility Name
Guangdong People's Hospital
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haosheng Jin, Doctor
Phone
+86 13825066891
Email
kinghaos@126.com
Facility Name
Zhujiang Hospital of Southern Medical University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510280
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yi Gao, Doctor
Phone
+86 18922345399
Email
gaoyi6146@163.com
Facility Name
The Third Affiliated Hospital of Sun Yat-sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510630
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chan Xie, Doctor
Phone
+86 13434383329
Email
happyxiechan@hotmail.com
Facility Name
Guangxi Medical University Affiliated Tumor Hospital
City
Nanning
State/Province
Guangxi
ZIP/Postal Code
530000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Feixiang Wu, Doctor
Phone
+86 13707873326
Email
wufx2013@163.com
Facility Name
Guizhou Provincial People'S Hospital
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550002
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jun Liu, Doctor
Phone
+86 13985519359
Email
LiuJun2018@126.com
Facility Name
The Affiliated Cancer Hospital of Guizhou Medical University
City
Guiyang
State/Province
Guizhou
ZIP/Postal Code
550008
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xing Wang, Doctor
Phone
+86 13608512435
Email
59434479@qq.com
Facility Name
Affiliated Hospital Of Zunyi Medical University
City
Zunyi
State/Province
Guizhou
ZIP/Postal Code
563000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lijin Zhao, Doctor
Phone
+86 13668526996
Email
386421696@qq.com
Facility Name
Hainan Provincial People's Hospital
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570311
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jincai Wu, Doctor
Phone
+86 18889765723
Email
wujincai021@126.com
Facility Name
The Second Affiliated Hospital of Hainan Medical University
City
Haikou
State/Province
Hainan
ZIP/Postal Code
570311
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Haifeng Lin, Bachelor
Phone
+86 13322060949
Email
13322060949@163.com
Facility Name
Affiliated Cancer Hospital of Harbin Medical University
City
Harbin
State/Province
Heilongjiang
ZIP/Postal Code
150081
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yubao Zhang, Doctor
Phone
+86 13936588077
Email
zhyb88077@sina.com
Facility Name
The First Affiliated Hospital of Henan University of Science and Technology
City
Luoyang
State/Province
Henan
ZIP/Postal Code
471000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dianbao Zhang, Doctor
Phone
+86 15038628192
Email
doctorzhangdianbao@163.com
Facility Name
The First Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yuling Sun, Doctor
Phone
+86 13837184328
Email
doctorssh@126.com
Facility Name
Henan Cancer Hospital
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450003
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongtao Hu, Doctor
Phone
+86 13592616373
Email
13592616373@163.com
Facility Name
Hunan Cancer Hospital
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jia Luo, Doctor
Phone
+86 13874994359
Email
luojia@hnca.org.cn
Facility Name
Hunan Provincial People's Hospital
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chuang Peng, Doctor
Phone
+86 15974220718
Email
1518364280@qq.com
Facility Name
The Third Xiang Ya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Feizhou Huang, Doctor
Phone
+86 18975186183
Email
Huangfeizhou1009@163.com
Facility Name
Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ledu Zhou, Doctor
Phone
+86 17373120367
Email
csuzld@126.com
Facility Name
Chifeng Municipal Hospital
City
Chifeng
State/Province
Inner Mongolia
ZIP/Postal Code
240000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhonghua Liu, Bachelor
Phone
+86 18047660067
Email
M18047660067@163.com
Facility Name
The First People's Hospital of Changzhou
City
Changzhou
State/Province
Jiangsu
ZIP/Postal Code
213000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xuemin Chen, Doctor
Phone
+86 13813587333
Email
czcxm007@126.com
Facility Name
Jiangsu Province People's Hospital
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiangcheng Li, Doctor
Phone
+86 18951999088
Email
drlixc@163.com
Facility Name
Affiliated Hospital of Nantong University
City
Nantong
State/Province
Jiangsu
ZIP/Postal Code
226006
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shudong Gu, Doctor
Phone
+86 15851392808
Email
gusdnt@foxmail.com
Facility Name
Nantong Tumor Hospital
City
Nantong
State/Province
Jiangsu
ZIP/Postal Code
226361
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bingfeng Shao, Bachelor
Phone
+86 13962981592
Email
ntzlsbf@163.com
Facility Name
Ganzhou People's Hospital
City
Ganzhou
State/Province
Jiangxi
ZIP/Postal Code
341099
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Song Zou, Bachelor
Phone
+86 13879757375
Email
1758771@qq.com
Facility Name
The Second Affiliated Hospital of Nanchang University
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
330000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Linquan Wu, Doctor
Phone
+86 13607912265
Email
wulqnc@163.com
Facility Name
Jilin Cancer Hospital
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130012
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ying Cheng, Doctor
Phone
+86 13943012851
Email
jl.cheng@163.com
Facility Name
The Second Hospital of Dalian Medical University
City
Dalian
State/Province
Liaoning
ZIP/Postal Code
116027
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Liming Wang, Doctor
Phone
+86 17709870007
Email
wangbcc259@163.com
Facility Name
The First Affiliated Hospital of Jinzhou Medical University
City
Jinzhou
State/Province
Liaoning
ZIP/Postal Code
121012
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hongzhi Sun, Doctor
Phone
+86 13840650008
Email
cmushz@163.com
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chaoliu Dai, Doctor
Phone
+86 18940251697
Email
daicl@sj-hospital.org
Facility Name
The Sixth People's Hospital of Shen Yang
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wei Wu, Bachelor
Phone
+86 18502460420
Email
wuwei19700420@sina.com
Facility Name
Liaoning Cancer Hospital
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110801
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiangdong Hua, Doctor
Phone
+86 13940126803
Email
LnzlHxd@163.com
Facility Name
Binzhou Medical University Hospital
City
BinZhou
State/Province
Shandong
ZIP/Postal Code
256699
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fangling Ning, Master
Phone
+86 15254311599
Email
ningfangling@126.com
Facility Name
Shandong Cancer Hospital
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250117
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lei Zhao, Doctor
Phone
+86 18615216153
Email
drzhaolei1974@163.com
Facility Name
The First Affiliated Hospital of Naval Medical University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200433
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jijin Yang, Doctor
Phone
+86 13801676237
Email
jijinyang@sina.com
Facility Name
Third Affiliated Hospital of Naval Medical University
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200433
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Feng Shen, Doctor
Phone
+86 13901651428
Email
shenfengehbh@sina.com
Facility Name
Baoji Central Hospital
City
Baoji
State/Province
Shanxi
ZIP/Postal Code
721000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gang Wang, Bachelor
Phone
+86 13892780368
Email
wangg1971@163.com
Facility Name
Heping Hospital Affiliated to Changzhi Medical College
City
Changzhi
State/Province
Shanxi
ZIP/Postal Code
46000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Buqiang Wu, Doctor
Phone
+86 13934055258
Email
wuli67@163.com
Facility Name
The Second Affiliated Hospital of Air Force Medical University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710038
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xilin Du, Doctor
Phone
+86 13709267808
Email
dxlin0705@163.com
Facility Name
First Affiliated Hospital of Xian Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Huanchen Sha, Doctor
Phone
+86 13152167215
Email
shahuanchen229@xjtufh.edu.cn
Facility Name
Xi'an International Medical Center Hospital
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710117
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Guohong Han
Phone
+86 13991969930
Email
13991969930@126.com
Facility Name
West China Hospital of Sichuan University
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hong Wu, Doctor
Phone
+86 18980601958
Email
wuhong7801@163.com
Facility Name
Affiliated Hospital of Southwest Medical University
City
Luzhou
State/Province
Sichuan
ZIP/Postal Code
646000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qinglian Wen, Doctor
Phone
+86 13518388130
Email
zlkgcpqlw666@163.com
Facility Name
Affiliated Hospital Of North Sichuan Medical College
City
Nanchong
State/Province
Sichuan
ZIP/Postal Code
637000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiaojie Ma, Master
Phone
+86 13458406996
Email
992437730@qq.com
Facility Name
Tianjin Third Central Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fengmei Wang, Doctor
Phone
+86 15522242696
Email
wangfengmeitj@126.com
Facility Name
Tianjin Medical University Cancer Institute & Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300181
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ningning Zhang, Doctor
Phone
+86 15822153931
Email
mail4ningning@163.com
Facility Name
Tianjin Cancer Hospital Airport Hospital
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300308
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Huikai Li, Doctor
Phone
+86 18622228639
Email
lihuikai@tjmuch.com
Facility Name
The First Affiliated Hospital of Xinjiang Medical University
City
Ürümqi
State/Province
Xinjiang
ZIP/Postal Code
830000
Country
China
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Weixin Reng, Doctor
Phone
+86 13909911031
Email
rwx1031@163.com
Facility Name
Sir Run Run Shaw Hospital Zhetiang University School of Medicine
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Xiujun Cai, Doctor
Phone
+86 13805738266
Email
srrsh_cxj@zju.edu.cn
Facility Name
Ningbo Medical Center Lihuili Hospital
City
Ningbo
State/Province
Zhejiang
ZIP/Postal Code
315000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shengdong Wu, Doctor
Phone
+86 13567886669
Email
arsdrell@hotmail.com
Facility Name
Shaoxing People's Hospital
City
Shaoxing
State/Province
Zhejiang
ZIP/Postal Code
312000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Baochun Lu, Doctor
Phone
+86 13002638081
Email
lbc111@yeah.net
Facility Name
Taizhou Hospital of Zhejiang Province
City
Taizhou
State/Province
Zhejiang
ZIP/Postal Code
317000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fabiao Zhang, Master
Phone
+86 13706760105
Email
Zhangfabiao@enzemed.com
Facility Name
The First Affiliated Hospital of Wenzhou Medical University
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Chang Yu, Doctor
Phone
+86 13906650823
Email
wzmcyc@126.com

12. IPD Sharing Statement

Learn more about this trial

Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.

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