PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis
Menstrual Bleeding, Heavy
About this trial
This is an interventional other trial for Menstrual Bleeding, Heavy
Eligibility Criteria
Inclusion Criteria: Regularly menstruating participants between 18-45 years of age Exclusion Criteria: Pregnancy within 3 months of enrollment Lactating at the time of enrollment Hormonal contraceptive use or use of the copper intrauterine device (IUD) Antifibrinolytic use Inherited or acquired bleeding disorder or anticoagulant use Known structural cause of HMB Inability to complete PBACs Unwilling to refrain from sexual intercourse for the two weeks prior to endometrial biopsy
Sites / Locations
- OHSURecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Heavy Menstrual Bleeding
Regular Mensural Bleeding
Participants with heavy menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.
Participants with normal menstrual bleeding will provide daily samples of menstrual blood for a single cycle and undergo a single endometrial biopsy for HEEC culture.