Addition of Aspirin to Standard of Care in Oral Cancer
Oral Cancer
About this trial
This is an interventional treatment trial for Oral Cancer
Eligibility Criteria
Inclusion Criteria: All Histologically proven cases of primary oral cancers. Stage T1 to T4, N0 to N3, M0 to M1. Age above 18. Karnofsky' performance status more than 70, ECOG 0 to 2 Hb >8.0 gm/dL Total count >4000 cu mm Platelet count >100000 Serum creatinine <1.0mg Liver enzymes up to 1.5 times normal Bilirubin <1.0mg Exclusion Criteria: Patients with acid peptic disease Pregnant and lactating women. Patients not willing to participate. Patients with known allergy to NSAID Patients with Asthma, rhinitis and nasal polyps Presence of viral fever Use of any other blood thinner like warfarin, heparin or low molecular weight heparin bleeding/blood-clotting disorders (such as hemophilia, vitamin K deficiency, low platelet count) pyruvate kinase or G6PD deficiency Patients receiving mifepristone, acetazolamide, corticosteroids, dichlorphenamide, methotrexate, valproic acid, herbal medications (such as ginkgo biloba) Patients with recent history of anti-viral vaccines
Sites / Locations
- Banaras Hindu UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Interventional arm
Standard of care
Aspirin 150mg PO daily along with standard of care
Standard of care as per the stage of disease and guidelines i.e. Surgery, Surgery with radiation or palliative chemotherapy as per investigators choice