Boosting Psychotherapy Effects by Means of Transcranial Direct Current Stimulation (PSYCHOBOOST)
Major Depressive Disorder
About this trial
This is an interventional treatment trial for Major Depressive Disorder
Eligibility Criteria
Inclusion Criteria: Ability to provide informed consent to study Ability to understand and speak the Italian language DSM-5 diagnosis of Major Depressive Disorder. Ongoing depressive episode of at least moderate intensity (HAM-D> 18) Exclusion Criteria: Previous tDCS sessions with significant side effects Positive personal history for seizures Positive family history for epileptic disease Positive personal history for neurological disease Positive personal history for head trauma with loss of consciousness Positive personal history for frequent and severe headaches Positive personal history for neurosurgical procedures Prior implantation of neurostimulation implants (DBS, VNS, etc.) Prior implantation of defibrillator or pace-maker Possibility of pregnancy or established pregnancy Substance or alcohol abuse in the past 6 months Positive personal history for schizophrenia or schizoaffective disorder Positive personal history of intellectual disability ("mental retardation") Current hospitalization Cardiac, respiratory, renal, hepatic failure, immunosuppression status
Sites / Locations
- Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
No Intervention
Experimental
Active tDCS
sham tDCS and MCT
active tDCS and MCT
Administration of active tDCS, not followed by MCT session, but by a usual visit psychiatric follow-up
Administration of sham tDCS, followed by MCT session
Administration of active tDCS, followed by MCT session