Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History (SAPIA)
Air Pollution, Atherosclerosis
About this trial
This is an interventional prevention trial for Air Pollution focused on measuring Air pollution, Particulate matter, Air purifier, HEPA filter, Atherosclerosis, Ischemic Heart Disease, Thrombosis, Cardiovascular Disease
Eligibility Criteria
Inclusion Criteria: Age between 65 and 84 years old; Weight ≥ 110 pounds; Nonsmokers for at least 1 year; Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records; Both English and Spanish speaking participants will be included in the recruitment; Live in the Los Angeles County. Exclusion Criteria: Have history of degenerative disease of the nervous system such as dementia and Alzheimer's; Currently have active cancer treatments; The residential house has already had HEPA filters; Participants will move out from the current residential address in the next 2 years; Participants will spend more than 1 month living outside the primary home; Have any health conditions that prohibit collecting health and covariate data and biospecimens; Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.
Sites / Locations
- Keck School of Medicine, University of Southern CaliforniaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
HEPA first and sham
Sham first and HEPA
This group of participants will be assigned to the intervention of HEPA filtration with the capacity to reduce indoor PM2.5 levels at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to sham filters (air purifier has the same appearance but HEPA filter is removed) for 9 months.
This group of participants will be assigned to the intervention of sham filtration with HEPA filter removed at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to the HEPA filtration for 9 months.