Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain

Erectile dysfunction cohort Inclusion Criteria: Cis-gendered heterosexual adult males ≥40 years old Stable relationship of more than 3 months duration with currently willing sexual partner and desire for penetration. Mild to moderate organic erectile dysfunction (IIEF-EF score 11-25) for at least 3 months PDE5I responsive or partially responsive ED (patients using PDE5I will be asked to discontinue PDE5I for 4 weeks prior to trial and remain off PDE5I for duration of study). Partially responsive ED is defined as inadequate response for desired sexual activity, or poorly maintained erection despite initially good response. Agreeable to attempt sexual intercourse at least 4 times per month for duration of study without being under the influence of alcohol or recreational drugs Morning total testosterone level over 300ng/dL Erectile dysfunction cohort Exclusion Criteria: History of spinal cord injury, severe lumbosacral disorder (radiculopathy, spinal stenosis) or other neurological disease affecting erectile functions (Multiple sclerosis, Alzheimer's, Parkinsons disease) Untreated hypogonadism (morning total testosterone <300 ng/dL) or on androgen deprivation therapy in the last 12 months Predominately psychogenic ED based upon expert clinician opinion Peyronie's disease, palpable plaque or curvature/penile anatomic abnormality that affects penetrative intercourse to any degree History of non-superficial penile surgery (penile prosthesis, penectomy, plication, grafting etc but not circumcision) History of penile injury or trauma (priapism, penile fracture) Use of intracavernosal injection for ED within the last year If diabetic, HbA1c 7.5 or higher within 3 months prior to trial Known corporal veno-occlusive dysfunction based on prior Doppler penile ultrasound Active smoker Poorly controlled hyperlipidemia Poorly controlled hypertension >130/80 mmHg Severe cardiac disease or history of myocardial infarction History of psychiatric disorder including bipolar disorder, current moderate or severe depression; patients using SSRI or psychotropic medication Severe ED based on IIEF-EF (score 10 or below) Acute prostatitis CP/CPPS cohort inclusion criteria: (all of the following) Adult males ≥40 years old Chronic pelvic pain with no obvious signs of infection in urine (<10 WBC per HPF in mid-stream urine) Agreeable to undergo PFPT CP/CPPS cohort exclusion criteria: History of spinal cord injury, severe lumbosacral disorder (radiculopathy, spinal stenosis), Multiple sclerosis, Alzheimer's, Parkinsons disease Acute prostatitis or any acute infection of the pelvic region History of pelvic trauma