Effect of Nocturnal Parenteral Nutrition on Bone Turnover and Energy Metabolism (NutriSync)
Intestinal Failure, Osteoporosis, Insulin Sensitivity
About this trial
This is an interventional other trial for Intestinal Failure focused on measuring Parenteral Nutrition, Intestinal Failure, Circadian misalignment
Eligibility Criteria
Inclusion Criteria: Home parenteral nutrition for at least 5 nights a week On home parenteral nutrition for more than 1 year No major changes in parenteral nutrition for 3 months prior to inclusion Exclusion Criteria: Parenteral infusion for more than 16 h a day Use of bone modifying drugs in the last 2 years Bone fractures in the past year Renal insufficiency (eGFR < 60 ml/min) HbA1c ≥48 mmol/ml Use of corticosteroids Shift work Performing intensive exercise (> 2 hours a day and > 3 times a week)
Sites / Locations
- Amsterdam University Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Nocturnal parenteral nutrition
Diurnal parenteral nutrition
Patients will receive nocturnal parenteral nutrition, starting at 8pm
Patients will receive diurnal parenteral nutrition, starting at 8am