Thromboprophylaxis in Good and Intermediate Prognosis Advanced Germ Cell Tumors (GIG-T)

Inclusion Criteria: Diagnosis of good or intermediate prognosis of Germ Cell Tumor (according to the International Germ Cell Cancer Collaborative Group) Older than 18 years Suitable for first-line cisplatin-based chemotherapy No prior systemic cytotoxic therapy Signed informed consent Additional criteria for patients who will be randomized (Venous Thromboembolic Event (VTE) high-risk patients): Lactate dehydrogenase higher than 1 Upper Normal Level and/or Body Surface Area higher than 1.9 and/or longer than 5 cm long axis retroperitoneal lymph nodes Patient should understand, sign, and date the written informed consent form prior to any protocol-specific procedures performed. Patient should be able and willing to comply with study visits and procedures as per protocol. Patients must be affiliated to a social security system or beneficiary of the same Exclusion Criteria: Brain metastasis History of VTE Concomitant use of anticoagulants or antiaggregants Renal impairment defined as creatinine clearance less than 50 ml/min using Cockcroft-Gault formula Hypersensitivity to enoxaparin sodium, heparin or its derivatives, including other low molecular weight heparins (LMWH) or to any of the excipients Any major surgery (i.e. open surgery lasting more than 45 minutes from opening to closure) within 4 weeks or planned during the study treatment period Severe uncontrolled high blood pressure (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg) Low baseline platelet count (< 100 X 10^9 /L) or history of heparin-induced thrombocytopenia Active clinically significant bleeding and conditions with a high risk of haemorrhage, including recent haemorrhagic stroke, gastrointestinal ulcer, presence of malignant neoplasm at high risk of bleeding, recent brain, spinal or ophthalmic surgery, known or suspected oesophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular abnormalities Extensive metastatic disease at high risk of bleeding, e.g. prevalent choriocarcinoma Participation in another clinical study with an investigational product during the last 4 weeks, and while on study treatment without the approval from sponsor Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving its consent