The Optimal Route of Fecal Microbiota Transplantation for Irritable Bowel Syndrome
IBS - Irritable Bowel Syndrome, Microbial Substitution
About this trial
This is an interventional treatment trial for IBS - Irritable Bowel Syndrome focused on measuring IBS, FMT, Fecal microbiota transplant, microbiome
Eligibility Criteria
Inclusion Criteria: Adult 18-70 years known of Finnish language IBS, (new or old diagnosis according to Roma III or IV criteria), all subtypes Informed consent Moderate to severe IBS symptoms, IBS-SSS > 175 Exclusion Criteria: Pregnancy Antibiotic or probiotic treatment, on-going or previous month Abuse of drugs, alcohol or medications Other diagnosis besides IBS causing the GI symptoms, such as IBD, microscopic colitis or bile acid diarrhea
Sites / Locations
- Central hospital of Päijät-HämeRecruiting
- Helsinki University HospitalRecruiting
- Turku university hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
FMT through colonoscopy
FMT through duodenogastroscopy
Plasebo
Patient gets FMT in ceacum and plasebo in duodenum.
Patient gets plasebo in ceacum and FMT in duodenum.
Patient gets plasebo in colonoscopy and in gastroscopy.