MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock (MADAME)
Sepsis, Multiorgan Failure, Inflammatory Response
About this trial
This is an interventional treatment trial for Sepsis focused on measuring Sepsis, Multiorgan Failure, Excessive Inflammatory Response, Manual Lymphatic Drainage, Lymphatic System, Septic Shock
Eligibility Criteria
Inclusion Criteria: diagnosis of septic shock at admission to ICU sepsis or suspicion of sepsis noradrenaline support required in order to maintain mean arterial pressure ≥ 65 mmHg serum lactate ≥ 2 mmol/L Exclusion Criteria: patients <18 years of age pregnant women with septic shock, in whom the pregnancy has been preserved patients with a history of heart failure with NYHA (New York Heart Association) classification ≥ III patients with a history of thromboembolic events patients with septic shock transferred from another department/hospital, if the length of stay at the previous workplace exceeded 72 hours patients with septic shock and an inauspicious prognosis, or in the phase of withdrawal of treatment patients with uncontrolled infection patients with septic shock who lack informed consent patients with septic shock, in whom the SOFA score decreased by more than 50% during the day following the withdrawal of noradrenaline (i.e. a subgroup of patients with a rapid improvement of the clinical course after the resolution of septic shock).
Sites / Locations
- University Hospital OstravaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Manual Lymphatic Drainage
Usual Care
In addition to usual care, daily manual lymphatic drainage will be performed for five consecutive days. After this period.
Usual care for patients with septic shock will be provided.