Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations
Tobacco Use Disorder
About this trial
This is an interventional basic science trial for Tobacco Use Disorder focused on measuring cue-reactivity, smokers, fNIRS, naturalistic setting, dorsolateral prefrontal cortex (dlPFC), orbitofrontal cortex (OFC), transcranial direct current stimulation (tDCS), craving, heart-rate variability (HRV), galvanic skin response (GSR)
Eligibility Criteria
Inclusion Criteria: informed consent daily cigarette consumption (already in the first half of the day) Exclusion Criteria: Acute or chronic disease (also anamnestic) that may affect brain metabolism: pre-existing diabetes mellitus (E10-E14) according to ICD-10 Renal insufficiency from stage 3 of the Kidney Disease Outcomes Quality Initiative onwards Uncontrolled hypertension (I10.x according to ICD-10) Moderate or severe traumatic brain injury (GCS 3-12) or 2nd- or 3rd-degree traumatic brain injury with loss of consciousness > 30 min Epilepsy (personal or in first-degree relatives). Currently present psychiatric or neurological disease Regular use of medications that affect blood flow (e.g., ASA).
Sites / Locations
- University Hospital for Psychiatry and Psychotherapy with PolyclinicRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
active transcranial direct current stimulation (tDCS)
sham transcranial direct current stimulation (tDCS)
A single application of transcranial direct current stimulation (tDCS), anodal stimulation of the left dlPFC placed (10-20 position F3) and the reference electrode on the arm, intensity 2mA, with retangular electrodes, size 35cm2, current intensity is ramped up to 2mA over a period of 20 seconds, duration 15 minutes
A single application of transcranial direct sham stimulation (tDCS), with sponge electrodes, placed over left dlPFC (10-20 position F3) and the reference electrode on the arm, with retangular electrodes 35cm2,intensity is ramped up to 2mA over a period of 20 seconds duration and then switched off again at the end of 20 s ramp. To ensure that there are no differences in perception, this is applied in both verum and sham stimulation, duration 15 min