EXPLORER Total Body PET/CT Imaging for Myofascial Pain
Myofascial Pain
About this trial
This is an interventional basic science trial for Myofascial Pain focused on measuring total body positron emission tomography
Eligibility Criteria
Inclusion Criteria: Ability to understand and willingness to sign an informed consent form Ability to adhere to the study visit schedule and all protocol requirements. Men and women ≥18 years of age Current self-report of chronic low back pain (cLBP) which has persisted for the past 3 months AND has resulted in pain on > 50% of days in the past 6 months At least one palpable nodule or taut band in paraspinal, quadratus lumborum, or gluteal muscles Reproduction of the patient's dominant pain with palpation of a muscle nodule or taut band Predominantly paramedian pain (may be uni-lateral or bi-lateral) Willing and able to lay motionless in a supine position on 2 different occasions: 60-70 minutes 18F-FDG scan 10-20 minutes 11C-Butanol Scan Willing and able to fast for at least 6 hours before and for the duration of the scan Willing to avoid strenuous exercise for 24 hours before the scan visit Exclusion Criteria: No Primary Care Physician History of any cancer (except non-melanoma skin cancer) History of spine infection (discitis or osteomyelitis) or spine tumor History of ankylosing spondylitis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, or lupus or other connective tissue diseases. Confounding conditions that are known to be responsible for inducing pain Implants at or in the region of the sites of interest Diagnosis of any vertebral fracture in the last 6 months Cauda equina syndrome or lumbar radiculopathy with functional motor deficit (strength<4/5 on manual motor testing) Spinal implants (including fixation hardware, spinal cord stimulator, intra-thecal pumps) Predominantly central pain Pain below the knee Positive straight leg raise test Symptomatic hip arthritis Fasting blood glucose level greater than 200 mg/dl before administration of 18F-FDG Self-reported history of dysphoria or anxiety in closed spaces Pregnant or lactating subjects Body weight more than 240 kg (529 pounds) due to the weight limitation of the scanner bed Prisoners Inability to speak, read, and write in the English language Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only Any other criteria, which would make the subject unsuitable to participate in this study as determined by the Principal Investigator (e.g., subject has a Legally Authorized Representative and cannot consent for him/herself)
Sites / Locations
- University of California Davis HealthRecruiting
Arms of the Study
Arm 1
Experimental
PET/CT scans
Each subject will undergo a dynamic 18F-FDG PET/CT scan and a dynamic 11C-butanol PET/CT scan on the EXPLORER total-body PET/CT system