Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy
Epithelial Ovarian Cancer, Acute Kidney Injury Due to Circulatory Failure
About this trial
This is an interventional treatment trial for Epithelial Ovarian Cancer focused on measuring Epithelial Ovarian Cancer, Acute Kidney Injury, Hyperthermic Intraperitoneal Chemotherapy, Sodium thiosulfate
Eligibility Criteria
Inclusion Criteria:(The following conditions must be met at the same time) Patients treated with HIPEC with cisplatin. Estimated survival > 12 weeks Age from 18 to 70 years Bone marrow reserve was well functioning. Leukocytosis ≥ 3.0×10^9/L, neutrophilic granulocyte ≥ 1.5 × 10^9/L, platelet count ≥ 100 × 10^9/L, and hemoglobin ≥ 80 g/L. Organs work well. AST ≤ 2.5 × ULN, ALT ≤ 2.5 × upper limit of normal(ULN), total serum bilirubin ≤ 1.5 × ULN, and creatinine ≤ 1.5 × ULN ECOG score 0-1 Patients voluntarily sign an informed consent form Exclusion Criteria:(None of which was eligible). Extensive abdominal adhesions HIPEC with Cisplatin for other medical conditions in the last 5 years. Receiving other drugs that cause kidney damage. Simultaneous use of amifotin for other diseases. Any situation of disease instability or potentially impact safety and adherence of patient. Chronic or acute nephropathy of any degree or other serious medical complications.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
HIPEC with sodium thiosulfate and hydration
HIPEC with hydration only
Sodium sulfate 9 g/m^2 combined with 0.9% natrium chloride 150 ml were instilled in 20 min as the time when HIPEC with cisplatin was beginning. After that, sodium sulfate 12 g/m^2 combined with 0.9% natrium chloride 1000 ml was pumped for 6 h . hydration: On the day of surgery, the day of HIPEC, and 24 hours after HIPEC, daily intravenous rehydration should be performed using natrium chloride, glucose chloride or potassium chloride. The amount of fluid to be replenished should not be less than 3000 milliliters.
hydration:On the day of surgery, the day of HIPEC, and 24 hours after HIPEC, daily intravenous rehydration should be performed using natrium chloride, glucose chloride or potassium chloride. The amount of fluid to be replenished should not be less than 3000 milliliters.