Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC)
Breast Cancer, Supplementation, Resistance Training

About this trial
This is an interventional supportive care trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria: Stage pTis-T1-T2-T3 pN0-1 M0 (early stage). Patients who have completed local treatment [surgery + radiotherapy (RT)] undergoing clinical follow-up in outpatient clinics with or without adjuvant hormone therapy treatment. Age: ≥18-60 years. ECOG Performance status from 0 to 1 (IK ≥80%). Body mass index above than 18.5. Without excessive alcohol consumption (men > 21 and women > 14 units/week). No current or previous illness or injury that may prevent participation and training. No recent systematic strength training. Not taking medications that are known to alter body composition (corticosteroids, metformin...). People who carry out some aerobic training will not be excluded (the activity carried out will be recorded weekly). Exclusion Criteria: Having received adjuvant or neoadjuvant chemotherapy. Metastatic carcinoma of the breast. Recurrence or second primary breast. History of previous cancer except previously treated basal cell carcinoma of the skin. Decompensated heart disease, uncontrolled hypertension (TAS>200 or TAD>110), heart failure (NYHA II or greater), heart failure or constrictive pericarditis, neutropenia, severe anemia (Hb<8.0 g/dl), blood count platelets <50,000 microL. Other health problems in which exercise is contraindicated Perform regular physical activity (150 min/week of moderate activity or 75 of vigorous activity), measured with the PVS questionnaire. Pregnancy. Criterion in the opinion of the investigator of inability to adequately understand the involvement and participation in this clinical study.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
No Intervention
Experimental
Experimental
Control Group
Resistance training group
Resistance training and creatine supplementation group
They receive physical activity and nutrition recommendations.
They will perform resistance training and placebo in the supplementation.
They will perform the same resistance training and will also receive creatine supplementation