Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants (NOSE)
Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
About this trial
This is an interventional treatment trial for Apnea of Prematurity focused on measuring Olfactory stimulation
Eligibility Criteria
Inclusion Criteria: Gestational age at birth: 23 0/7 to 31 6/7 weeks Postnatal age: >72 hours old Respiratory support: nCPAP Treatment with caffeine citrate for apnea of prematurity Written informed consent by one of the patient's parents Exclusion Criteria: Olfactory impairment such as choanal atresia Intraparenchymal intracranial hemorrhage or intraventricular hemorrhage with ventricular dilation Culture-proven sepsis during the study period or any acute clinical deterioration requiring an intervention such as intubation or a new start of antibiotic treatment. Severe congenital malformation adversely affecting life expectancy
Sites / Locations
- Department of Neonatology, Newborn Research, University Hospital and University of Zurich,Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Aroma
Control
Preterm infants on CPAP support will be exposed to either vanilla or strawberry aroma. A pen with and without vanilla or strawberry aroma will be used to apply the aroma to the inner surface of the CPAP mask.
Preterm infants on CPAP support will be exposed to placebo. The placebo pen will contain the carrier solution and natural coloring agents but no aroma.