Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD
Laryngopharyngeal Reflux
About this trial
This is an interventional treatment trial for Laryngopharyngeal Reflux focused on measuring Laryngopharyngeal Reflux, proton pump inhibitors, Jinsangliyan capsule, treatment, therapeutic evaluation
Eligibility Criteria
Inclusion Criteria: The patients who met the clinical diagnostic criteria for LPRD (by asking history and laryngoscopy, RSI score >13 or RFS score >7 points); No antacids or gastrointestinal motility drugs were taken within 2 weeks before enrollment. Be aged 18-65 years with no gender restriction; Patients understood and agreed to participate in this study and signed an informed consent form. Exclusion Criteria: complicated with acute upper respiratory tract infection; combined with one of the following diseases of the digestive system: peptic ulcer, history of gastroesophageal and duodenal surgery, Zollinger-Ellison syndrome, pyloric obstruction, primary esophageal motility disorders (e.g., achalasia, scleroderma, primary esophageal spasm), drug-induced esophagitis, mycotic esophagitis, gastrointestinal malignant tumor; patients with severe primary diseases of heart, brain, liver, lung, kidney, blood and endocrine system, and severe psychosis without effective control; those who could not take medicine during pregnancy or lactation, or who were allergic to the drugs used in this study; Or unable to cooperate with medication and complete relevant records due to various circumstances; patients who have participated or are participating in other drug clinical trials within three months; patients judged by the investigator to be ineligible for trial participation.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
experimental group
control group
Jinsang Liyan Capsule: oral, 0.4g/ capsule, 4 capsules, twice a day, for 8 weeks; Rabeprazole enteric-coated tablets: taken orally before breakfast, 10mg/ tablet, 2 tablets at a time, once a day, for 8 weeks;
Jinsang Liyan Capsule placebo: oral, 0.4g/ capsule, 4 capsules, twice a day, for 8 weeks; Rabeprazole enteric-coated tablets: taken orally before breakfast, 10mg/ tablet, 2 tablets at a time, once a day, for 8 weeks;