Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD) (ReSCInD)

Inclusion Criteria: Patients with suspected acute ischemic stroke with symptom onset (last-seen-well) until Investigational drug application of less than 12 hours. Consent to participate in the study. Age ≥ 18 years. NIHSS ≥10 at admission. Exclusion Criteria: Presence of any of the following conditions: Sinus or cerebral venous thrombosis, intracerebral haemorrhage, subarachnoid haemorrhage on qualified imaging (cCT with CT-A or MRI with MR-A). However, petechial haemorrhagic transformations of the index infarct and cerebral microhaemorrhages may be included. Active malignant tumour disease in the last 6 months. Current known immunosuppression due to immunomodulatory medication with immunosuppressive dose or underlying immunosuppressive disease (e.g. HIV). Acute fulminant infectious disease in the last 7 days (fever > 38.5°C or suspected by the Investigator). Breastfeeding or pregnant woman, women of childbearing age without known use of contraceptives with positive urine or serum beta-human choriogonadotropin test. Ischemic stroke or myocardial infarction in the previous 30 days. Surgery in the previous 30 days, except minor dermatological or gynaecological surgery without anaesthesia and wound healing disorders and patients with thrombectomy. Estimated or known weight > 100 kg. Known allergies or intolerance to dornase alfa (Pulmozyme) or recombinant protein products derived from Chinese hamster ovary cells. Thrombocytopenia, leukocyte count <1500/μl. Known participation in another clinical trial investigating a drug and/or medical product in the last 7 days before study inclusion. Severe renal insufficiency with GFR≤29 ml/min/ 1.73m³ and/or renal insufficiency requiring dialysis.