Antiemetic Prophylaxis With Fosaprepitant and Ondansetron in Patients Undergoing Thoracic Surgery
Postoperative Nausea and Vomiting, Anesthesia Complication, Thoracic Diseases
About this trial
This is an interventional treatment trial for Postoperative Nausea and Vomiting
Eligibility Criteria
Inclusion Criteria: aged between 18 and 70 years physical status classified by the American Society of Anesthesiologists (ASA) scale as I to III Apfel score ≥ 2 undergoing thoracoscopic pneumonectomy Exclusion Criteria: Preoperative disorders of consciousness body mass index (BMI) > 35 kg/m2 occurrence of episodes of nausea or vomiting within 24 h prior to surgery、motion sickness,、previous PONV、people who smoke、people with alcoholism、use of corticosteroids, psychoactive or antiemetic drugs,、hypersensitivity to the study medications serious kidney, liver, lung, heart, brain or bone marrow disease conversion from thoracoscopic pneumonectomy to conventional pneumonectomy participation in another clinical study.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Fosaprepitant
Ondansetron
Participants undergoing thoracoscopic pneumonectomy will receive 150 mg of fosaprepitant and 100 ml of normal saline, administer intravenously after the induction of general anesthesia.
Participants undergoing thoracoscopic pneumonectomy received 8 mg of ondansetron and 100 ml of normal saline, administer intravenously after the induction of general anesthesia.