Efficacy and Safety of HRS9531 Injection in Obese Subjects Without Diabetes

Inclusion Criteria: Able and willing to provide a written informed consent; Male or female subjects, 18-65 years of age at the time of signing informed consent; At screening visit, 28.0 ≤BMI≤ 40.0 kg/m2; Diet and exercise control for at least 3 months before screening visit, and less than 5 kg self-reported change within the last 3 months. Exclusion Criteria: Presence of - clinically significant lab or ECG results that may affect the evaluation of the efficacy or safety of the study drug at screening visit; Uncontrollable hypertension; PHQ-9 score ≥15; Medical history or illness that affects your weight; History of diabetes; Acute infection, acute trauma, or medium to large surgery within 1 month prior to screening; History of acute cardiovascular and cerebrovascular diseases within 6 months prior to screening; Any organ-system malignancies developed within 5 years except for cured local basal cell cancer of the skin and in-situ cancer of the cervix; Confirmed or suspected depression, bipolar disorder, suicidal tendencies, schizophrenia, or other serious mental illness; History of alcohol and/or substance abuse or drug abuse within 1 year prior to screening; Use of any medication or treatment that may have caused significant weight change within 3 months; History of bariatric surgery; Known or suspected hypersensitivity to trial product(s) or related products; Participation in other clinical trials for any weight-loss indication within 3 months prior to screening, or participation in other clinical trials for any drug or medical device within 1 month prior to screening; history of blood donation or blood loss in the 3 months before screening, or blood transfusion in the 2 months before screening; Surgery is planned during the trial; Mentally incapacitated or speech-impaired; Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using an adequate contraceptive method; Researchers and relevant staff of the research Centre or other people directly involved in the implementation of the programme, and their immediate family members.