Enhanced Hippocampal Neuroplasticity for Surfacing of Inaccessible Traumatic Memories in Veterans With PTSD
PTSD, Peritraumatic Amnesia
About this trial
This is an interventional treatment trial for PTSD
Eligibility Criteria
Inclusion Criteria: Diagnosis of PTSD A history of trauma of at least one course of trauma-focused psychotherapy The presence of peri-traumatic amnesia Exclusion Criteria: A history of traumatic brain injury or any other known brain pathology except PTSD Active smoking Drugs or alcohol abuse other than prescribed cannabis Active asthma, lung pathology, epilepsy or otolaryngological disease incompatible with HBOT The presence of shards or another contraindication for MRI
Sites / Locations
- Assaf-Harofeh Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
HBOT
HBOT + hippocampal training
Participants will be treated in a multiplace chamber (HAUX-Life-Support GmbH) for a total of 60 daily sessions, five days a week. Each session will consist of 90 minutes exposure to 100% oxygen at 2 ATA (atmospheres), with five-minute air brakes every 20 minutes.
Participants will be treated in a multiplace chamber (HAUX-Life-Support GmbH) for a total of 60 daily sessions, five days a week. Each session will consist of 90 minutes exposure to 100% oxygen at 2 ATA, with five-minute air breaks every 20 minutes. Hippocampal training: This will combine physical and cognitive training. Training will be given 3 times per week, prior to the next HBOT, and more than 20 hours after the last HBOT session.