Comparative Efficacy of Tacrolimus and Clobetasol Propionate in Alopecia Areata

Comparative Efficacy of Tacrolimus 0.1% and Clobetasol Propionate 0.05% in the Treatment of Alopecia Areata

Methodology: The 70 patients of age 20 to 50 years presented to the out-patient department of CMH Abbottabad suffering from alopecia areata were enrolled. The non-probability consecutive sampling technique was used. Patient in group-A applied clobetasol propionate 0.05% twice daily, whereas Group-B applied topical tacrolimus 0.1% twice daily for upto 3 months. The Patients were assessed at baseline, 4th weeks, 8th week and 12th week after treatment of each session. Hair loss was calculated from SALT score at presentation and on follow-up after 3 months. The degree of response was assessed on the basis of hair re-growth as excellent (>75% re-growth), Marked (51-75% re-growth), moderate (26-50% re-growth), or slight (≤25% re-growth). To determine statistical significance χ2-square test, taking p-value <0.05 as significant, was used.

The degree of response was assessed on The basis of hair regrowth as excellent, marked, moderate or slight.

The degree of response was assessed on the basis of hair regrowth as excellent (>75% regrowth), marked (51-75% regrowth), moderate (26-50% regrowth), or slight (≤25% regrowth)

Inclusion Criteria: Patients age 20 to 50 years Both male and female Duration of illness less than 2 months those who never received any treatment before Exclusion Criteria: Patients having duration of alopecia greater than 2 months Atypical alopecia areata i.e., Alopecia universalis etc Hypersensitivity history to topical corticosteroids or tacrolimus patients taking any systemic immune suppression pregnancy/lactation