Preoperative Treatment of HR+/HER2+Breast Cancer With Pirotinib, Trastuzumab and AI Research (PYTHON)

Inclusion Criteria: Female initial treatment patients aged ≥ 18 years and ≤ 75 years old ECOG score 0-1 Stage II-IIIA invasive breast cancer, diameter ≥ 20mm HER2 positive (IHC score of 3+, or 2+and ISH test positive) ER>10% Doctors choose to use letrozole/anastrozole for endocrine therapy The definition of menopause includes any of the following: (Previous bilateral oophorectomy; Age)≥ 60 years old; Age<60 years old and without chemotherapy, tamoxifen, toremifen, or ovarian suppressionUnder normal conditions, menopause lasts for ≥ 12 months, and follicle stimulating hormone (FSH) and estradiol are within the postmenopausal range;If receiving tamoxifen or toremifen and age<60 years, FSH and plasma estradiolWithin the postmenopausal range) Left ventricular ejection fraction (LVEF) ≥ 50% 12 lead electrocardiogram: QT interval (QTcF) corrected by Fridericia method for females<470ms； The functional level of the main organs must meet the following requirements: blood routine: ANC ≥ 1.5 × 109/L； PLT≥90 × 109/L； Hb≥90 g/L；Blood biochemistry: TBIL ≤ 2.5 × ULN； ALT and AST ≤ 2.5 × ULN； BUN and Cr ≤ 1.5 × ULN； For female subjects who have not undergone menopause or surgical sterilization, during the treatment period and during the study treatment Agree to abstain or use effective contraceptive methods for at least 2 months after the next administration; .Volunteer to join this study, sign informed consent, have good compliance, and be willing to cooperate with follow-up. Exclusion Criteria: Stage IIIB-IV or inflammatory breast cancer Metastatic tumor Previous or concurrent malignant tumors, whose natural history or treatment may interfere with the safety of the research protocol Patients evaluated for sex or efficacy are not eligible to participate in this trial, but basal or squamous cell skin Except for cancer, cervical cancer in situ or bladder cancer, or the subject has no disease (other cancer) to survive At least 5 years. Active infections that require systemic treatment Has used any medication in this study within 14 days prior to enrollment Major surgery (excluding biopsy) performed within 14 days before enrollment Gastrointestinal dysfunction or diseases may seriously affect the absorption of drugs in this study (such as ulcerative Disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection) or Severe damage to the ability to swallow capsules/tablets Known history of myelodysplastic syndrome or acute myeloid leukemia Have a history of abdominal fistula, gastrointestinal perforation, or abdominal abscess within 28 days Have any history of cerebrovascular accident (CVA) or transient ischemic attack within 12 months Within 6 years, there is a history of acute coronary syndrome (including myocardial infarction, unstable angina, coronary artery bypass grafting, coronary angioplasty or stent implantation) or symptomatic pericarditis