A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China (HERITAGE)
Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment
About this trial
This is an interventional prevention trial for Cognitive Impairment
Eligibility Criteria
Inclusion Criteria: At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8>=3 and/or 5-min MoCA >, < 11) Free of physical disabilities that preclude participation in the study Willing to complete all study-related activities for 24 months Willing to be randomized to either lifestyle intervention group Exclusion Criteria: Diagnosed dementia patients Diagnosed major depression or other neuropsychological diseases Malignant diseases Symptomatic cardiovascular disease Revascularization within one year Severe loss of vision, hearing or communicative ability
Sites / Locations
- School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, ChinaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Structured Multi-domain Intervention
Self-Guided Intervention
Multi-domain structured intervention will be tailored by Chinese traditional and social norms and then conducted among the intervention group. That includes: Nutritional and dietary instruction, Cognitive training, Physical exercises, and Vascular risks monitoring and control.
Every 6-12 months, control group will receive a regular health education campaign to encourage a healthy lifestyle and a regular health monitoring and examination of blood pressure, weight, fasting blood glucose and liposome group