search
Back to results

Nurse Family Partnership for Women With Previous Live Births

Primary Purpose

Pregnancy, High Risk, Child Development, Post Partum Depression

Status
Recruiting
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Nurse Family Partnership
Sponsored by
University of Colorado, Denver
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Pregnancy, High Risk focused on measuring Nurse Family Partnership, Home Visiting

Eligibility Criteria

16 Years - undefined (Child, Adult, Older Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria: pregnant at 28 weeks EGA or less history of previous live birth covered by Medicaid or Medicaid-eligible at least one of the following risks or adversities -age 19 or younger, no high school degree or equivalent, homeless (using a standardized definition), previous birth with low birth weight or prematurity, previous pregnancy with severe morbidity based on Centers for Disease Control definition, current pregnancy within 18 months of previous pregnancy, currently using tobacco or marijuana, history of substance use disorder, and self-identification as Black/African American (as a marker of facing the adversity of structural racism). Exclusion Criteria: unable converse and demonstrate adequate understanding to provide consent for study participation in English are already enrolled in a home-visiting intervention with this pregnancy have previously been enrolled in NFP under the age of 16 years. Note that we propose to exclude those who don't speak English from our study because the community served by the two NFP delivery sites participating in our study is mostly English-speaking. However, those who don't speak English are not excluded from participation in NFP, and NFP routinely provides services to all eligible families regardless of language spoken using bilingual/multilingual nurses when available or using interpretation services. NFP materials for nurses to use with families, known as 'facilitators', are available in several languages. In the rare circumstance that a pregnant woman is excluded from participating in our study based on language, they will not be excluded from receiving NFP.

Sites / Locations

  • Nationwide Children's HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

No Intervention

Arm Label

Intervention (NFP)

Control

Arm Description

In the standard NFP intervention, low-income pregnant women are recruited to voluntarily join the program through their 28th week of pregnancy. Enrolled women receive home visits from a nurse. The visits can occur in-person or via telehealth. In-person visits can occur in the client's home or in another community location agreed upon by the client and the nurse (such as a library or coffee shop). The typical schedule for visits is weekly during the first month after enrollment, every two weeks until the birth of the infant, weekly during the post-partum period, then every two to four weeks until child age two.

The control group will receive usual care for pregnant people, which may include home visiting services from another source other than NFP. Participants who are randomly selected to receive other services will be given information about other services for which they may qualify and information about how to access those services.

Outcomes

Primary Outcome Measures

Presence of Pregnancy-related hypertension
High Blood Pressure associated with pregnancy
Change in maternal tobacco use by cotinine
Measured by cotinine level in saliva
Change in self reported maternal tobacco use
Measured by self-report (yes/no)
Index child language development measured by the Bayley IV language subscale
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Index child language development measured by the MacArthur Bates CDI (Communicative Development Inventories)
Percentage out of 100; 100 being best outcome

Secondary Outcome Measures

Number of participants with infection during pregnancy based on medical record review
Receipt of screening for common infections; if positive, receipt of appropriate treatment
Number of infants born with weight less than 2500 grams per medical record review
Number of infants born less than 34 weeks gestation per medical record review
Change in self-reported maternal substance use
Past month use per self-report (yes/no)
Initiation and continuation of any breastfeeding per maternal report
Percentage of well-child visits attended for index child per medical record review
Number out of 7 visits by 12 months
Index child immunization use per medical record review
Immunizations up-to-date for age at 18 months
Index child emergency room visits for serious preventable injuries and sentinel injuries for child abuse.
Visit rate and reason for visit per medical record review
Index child hospitalization for injuries
Number of days hospitalized for injury per medical record review
Change in quality of home environment measured by the HOME (Home Observation Measurement of the Environment) Inventory short form
53 yes/no measures; score scaled based on child age, self-report and interviewer observation
Change in quality of home environment measured by the CHAOS (Confusion, Hubbub and Order Scale) Scale
On a scale of 1-15, The higher the score the higher the level of environmental chaos in the home
Mother-child interaction measured by the Dyadic Assessment of Naturalistic Caregiver-child Experiences (DANCE)
Video recorded interactions are scored by trained research assistants, for each behavior the frequency and proportion of time spent is recorded.
Child's developmental index measured by Bayley IV developmental assessment
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Index child's social and emotional development based on Bayley IV socio-emotional subscale
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Index child's social and emotional development measured by the Child Behavior Checklist (CBCL) (maternal report)
54 question scored on a scale of 0-2; lower scores are more emotionally regulated children
Change in maternal perceived stress measured by Perceived Stress Scale (maternal report)
Scale of 0-40 based on 10 questions; 0-13 would be considered low stress. Scores ranging from 14-26 would be considered moderate stress. Scores ranging from 27-40 would be considered high perceived stress.

Full Information

First Posted
April 27, 2023
Last Updated
May 23, 2023
Sponsor
University of Colorado, Denver
Collaborators
Nationwide Children's Hospital, University of Rochester
search

1. Study Identification

Unique Protocol Identification Number
NCT05887115
Brief Title
Nurse Family Partnership for Women With Previous Live Births
Official Title
Randomized Clinical Trial of Nurse Family Partnership for Women With Previous Live Births
Study Type
Interventional

2. Study Status

Record Verification Date
May 2023
Overall Recruitment Status
Recruiting
Study Start Date
March 31, 2023 (Actual)
Primary Completion Date
February 28, 2026 (Anticipated)
Study Completion Date
February 28, 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University of Colorado, Denver
Collaborators
Nationwide Children's Hospital, University of Rochester

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The goal of this clinical trial is to test the Nurse Family Partnership (NFP) in mothers with previous live births (multiparous or multip individuals). The main aims are: Specific Aim 1-Determine the effectiveness of NFP among multiparous women for reducing maternal morbidity and improving pregnancy outcomes. Specific Aim 2-Determine the effectiveness of NFP among index children (child from pregnancy when mother was enrolled) of multiparous women for improving child outcomes. Specific Aim 3 (Exploratory)-In preparation for a future study of the effects of preventive home-visiting programs on mother-index child-sibling triads, describe siblings (characteristics, role, influence) in the context of nurse home-visiting and evaluate the effectiveness of NFP on outcomes for prior-born siblings younger than 6 years old living in the home, including cognitive development, socioemotional development, and identification and referral to needed services.
Detailed Description
The proposed study will be conducted in partnership with two or more NFP sites in Columbus and Dayton, Ohio. Investigators will work with the prenatal care clinics and pregnancy resource referral centers to identify a process that fits into each site's flow for identifying and recruiting eligible multiparous pregnant women at 28 weeks EGA (estimated gestational age) or less to participate in the study. The study will recruit 800 women to participate. Half will be randomized to receive NFP and half will be randomized to receive any other community services available outside of NFP. Researchers will compare the intervention group with the control group to test the effects described in the Aims above (as outlined in the following hypotheses). Hypothesis 1-Compared to multiparous women who receive usual care, women who receive NFP will have reductions in pregnancy-related hypertension and tobacco use. Hypothesis 2-Compared to children of women who receive usual care, those whose mothers receive NFP will have improved language development. Women will be asked to participate in seven data collection episodes at study enrollment/baseline, 36 to 40 weeks pregnancy, 6 to 8 weeks postpartum, and child ages 6, 12, 18, and 24 months. Researchers will use the following data sources for this study: 1) data routinely collected by the NFP team to determine enrollment and engagement in the NFP program of study participants randomized to NFP; 2) self-administered and interview surveys of study participants collected by the research assistant; 3) formal observation-based assessment tools (such as the Bayley assessment of child development) administered by the research assistant; 4) videos of parent-child interactions recorded by the research assistant and coded by parenting experts; 5) saliva samples (mothers) collected by the research assistant or self-collected by the participant with guidance from the research assistant; 6) data from medical record review of mothers and their children; and 7) birth certificate data. The research assistants will conduct all the primary data collection from mother-child dyads who have agreed to participate in the trial, and primary data collection will be separate from NFP program delivery which will be conducted by the NFP nurses. Primary data collection will occur at 7 time points as described above. Primary data collection will occur in the participants' homes or at another location where the participant and research assistant feel comfortable (such as a meeting room in a public library). The majority of measures could be collected in a variety of settings with the exception of the video-taped interactions between parents and children which would ideally occur in the child's natural environment. The postpartum and 12 month visits only involve maternal report measures and can be conducted by telephone/video using online surveys. The research assistant will record where each data collection episode occurred. The research assistant will also record all attempts made to contact study participants for data collection and missed episodes of data collection (i.e., if a visit were arranged and the participant were not available). The research assistant will be trained regarding appropriate collection, transport, and storage procedures for biologic samples and will be trained to conduct the Bayley assessment of child development.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pregnancy, High Risk, Child Development, Post Partum Depression
Keywords
Nurse Family Partnership, Home Visiting

7. Study Design

Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Care ProviderInvestigator
Masking Description
Research assistants will not collect any NFP program data - only equivalent research data in both control and NFP groups. Research assistants will remind participants not to tell the researchers which group they are in prior to each research data collection. We will also record in our participant tracking database if a researcher is ever "unmasked" (e.g., saw the NFP folder/ materials/participant mentioned their NFP nurse during an interview). Similarly, the nurses providing NFP will not be aware of which of their clients are involved in the study.
Allocation
Randomized
Enrollment
880 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Intervention (NFP)
Arm Type
Active Comparator
Arm Description
In the standard NFP intervention, low-income pregnant women are recruited to voluntarily join the program through their 28th week of pregnancy. Enrolled women receive home visits from a nurse. The visits can occur in-person or via telehealth. In-person visits can occur in the client's home or in another community location agreed upon by the client and the nurse (such as a library or coffee shop). The typical schedule for visits is weekly during the first month after enrollment, every two weeks until the birth of the infant, weekly during the post-partum period, then every two to four weeks until child age two.
Arm Title
Control
Arm Type
No Intervention
Arm Description
The control group will receive usual care for pregnant people, which may include home visiting services from another source other than NFP. Participants who are randomly selected to receive other services will be given information about other services for which they may qualify and information about how to access those services.
Intervention Type
Behavioral
Intervention Name(s)
Nurse Family Partnership
Intervention Description
During NFP visits, the nurse: 1) engages in a therapeutic nurse-client relationship focused on promoting client abilities and behavior change to protect and promote her own health and child's health; 2) provides service coordination based on client's identified needs, referring to available community services; 3) follows NFP Visit Guidelines tailoring them to the strengths and challenges of each family; 4) works with client to support a healthy pregnancy by recognizing and reducing risk factors and promoting prenatal health care, healthy diet, exercise, and stress management; and 5) gathers data on program implementation and maternal and child health. The visits include content from six domains: personal health, environmental health, life-course, maternal role, family and friends, and health and human services. Nurses use educational materials to address the content from the six domains with their clients.
Primary Outcome Measure Information:
Title
Presence of Pregnancy-related hypertension
Description
High Blood Pressure associated with pregnancy
Time Frame
Birth of index child
Title
Change in maternal tobacco use by cotinine
Description
Measured by cotinine level in saliva
Time Frame
Less than 28 weeks gestation and 36 weeks gestation
Title
Change in self reported maternal tobacco use
Description
Measured by self-report (yes/no)
Time Frame
Less than 28 weeks gestation, 36 weeks gestation, index child age 6 months, 12 months, and 24 months.
Title
Index child language development measured by the Bayley IV language subscale
Description
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Time Frame
Index child age 24 months
Title
Index child language development measured by the MacArthur Bates CDI (Communicative Development Inventories)
Description
Percentage out of 100; 100 being best outcome
Time Frame
Index child age 24 months
Secondary Outcome Measure Information:
Title
Number of participants with infection during pregnancy based on medical record review
Description
Receipt of screening for common infections; if positive, receipt of appropriate treatment
Time Frame
Index child age 1 month
Title
Number of infants born with weight less than 2500 grams per medical record review
Time Frame
Index child age 1 month
Title
Number of infants born less than 34 weeks gestation per medical record review
Time Frame
Index child age 1 month
Title
Change in self-reported maternal substance use
Description
Past month use per self-report (yes/no)
Time Frame
Less than 28 weeks gestation, 36 weeks gestation, index child ages 6, 12, 18, 24 months
Title
Initiation and continuation of any breastfeeding per maternal report
Time Frame
Index child age 1 month, 6 months and 12 months
Title
Percentage of well-child visits attended for index child per medical record review
Description
Number out of 7 visits by 12 months
Time Frame
Index child age 18-24 months
Title
Index child immunization use per medical record review
Description
Immunizations up-to-date for age at 18 months
Time Frame
Record review at index child age 18-24 months
Title
Index child emergency room visits for serious preventable injuries and sentinel injuries for child abuse.
Description
Visit rate and reason for visit per medical record review
Time Frame
Index child age birth to 24 months, collected at 24 months
Title
Index child hospitalization for injuries
Description
Number of days hospitalized for injury per medical record review
Time Frame
Record review at index child age 24 months
Title
Change in quality of home environment measured by the HOME (Home Observation Measurement of the Environment) Inventory short form
Description
53 yes/no measures; score scaled based on child age, self-report and interviewer observation
Time Frame
36 weeks gestation, index child age 18 months
Title
Change in quality of home environment measured by the CHAOS (Confusion, Hubbub and Order Scale) Scale
Description
On a scale of 1-15, The higher the score the higher the level of environmental chaos in the home
Time Frame
36 weeks gestation, index child age 24 months
Title
Mother-child interaction measured by the Dyadic Assessment of Naturalistic Caregiver-child Experiences (DANCE)
Description
Video recorded interactions are scored by trained research assistants, for each behavior the frequency and proportion of time spent is recorded.
Time Frame
Index child age 18 months
Title
Child's developmental index measured by Bayley IV developmental assessment
Description
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Time Frame
Index child age 24 months
Title
Index child's social and emotional development based on Bayley IV socio-emotional subscale
Description
Scaled, age-adjusted score from 1-19 with 19 being best outcome
Time Frame
Index child age 24 months
Title
Index child's social and emotional development measured by the Child Behavior Checklist (CBCL) (maternal report)
Description
54 question scored on a scale of 0-2; lower scores are more emotionally regulated children
Time Frame
Index child age 24 months
Title
Change in maternal perceived stress measured by Perceived Stress Scale (maternal report)
Description
Scale of 0-40 based on 10 questions; 0-13 would be considered low stress. Scores ranging from 14-26 would be considered moderate stress. Scores ranging from 27-40 would be considered high perceived stress.
Time Frame
Less than 28 weeks gestation and index child age 6 months

10. Eligibility

Sex
Female
Gender Based
Yes
Gender Eligibility Description
Participant must be pregnant to participate; can identify as any gender
Minimum Age & Unit of Time
16 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: pregnant at 28 weeks EGA or less history of previous live birth covered by Medicaid or Medicaid-eligible at least one of the following risks or adversities -age 19 or younger, no high school degree or equivalent, homeless (using a standardized definition), previous birth with low birth weight or prematurity, previous pregnancy with severe morbidity based on Centers for Disease Control definition, current pregnancy within 18 months of previous pregnancy, currently using tobacco or marijuana, history of substance use disorder, and self-identification as Black/African American (as a marker of facing the adversity of structural racism). Exclusion Criteria: unable converse and demonstrate adequate understanding to provide consent for study participation in English are already enrolled in a home-visiting intervention with this pregnancy have previously been enrolled in NFP under the age of 16 years. Note that we propose to exclude those who don't speak English from our study because the community served by the two NFP delivery sites participating in our study is mostly English-speaking. However, those who don't speak English are not excluded from participation in NFP, and NFP routinely provides services to all eligible families regardless of language spoken using bilingual/multilingual nurses when available or using interpretation services. NFP materials for nurses to use with families, known as 'facilitators', are available in several languages. In the rare circumstance that a pregnant woman is excluded from participating in our study based on language, they will not be excluded from receiving NFP.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Natalie J Murphy
Phone
7206722402
Email
natalie.murphy@cuanschutz.edu
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mandy A Allison, MD, MSPH
Organizational Affiliation
University of Colorado School of Medicine
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Deena Chisolm, PhD
Organizational Affiliation
Nationwide Children's Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Nationwide Children's Hospital
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43205
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ashley Banks, MPH
Phone
614-722-3756
Email
Ashley.Banks@nationwidechildrens.org
First Name & Middle Initial & Last Name & Degree
Deena Chisolm, PhD

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
We will share de-identified individual participant data with researchers who desire to conduct additional analyses. Investigators who are interested in accessing de-identified individual participant data should e-mail the Prevention Research Center for Family and Child Health (FamilyChildPRC@cuanschutz.edu) to request an application for data use. The leadership team at the PRC (Prevention Research Center for Family and Child Health) will review the application and determine whether to grant access. The criteria are listed below under 'Access Criteria'.
IPD Sharing Time Frame
Data will become available at the close of currently funded study (January 2027) and will be available for 10 years (through December 2036).
IPD Sharing Access Criteria
Criteria used in the review are as follows: Proposal has reasonable scientific merit; allows data to be put to good scientific use. Proposal is both theoretically and empirically sound. Statistical power is appropriate given level of project Likely usefulness for investigator. Likely to contribute to existing knowledge base Investigator's collaborator should be associated with our team. They provide link to our team, may provide access to data or at least communicate what data are available. Proposed analyses have not already been completed or proposed by other collaborators or members of the research team. Demands on current staff time are minimal including: Variable construction Statistical consultation Providing computer access/resources Data cleaning Providing access to data Current load of staff, including existing outside projects
Citations:
PubMed Identifier
28402829
Citation
Bor J, Cohen GH, Galea S. Population health in an era of rising income inequality: USA, 1980-2015. Lancet. 2017 Apr 8;389(10077):1475-1490. doi: 10.1016/S0140-6736(17)30571-8.
Results Reference
background
PubMed Identifier
17875251
Citation
Freudenberg N, Ruglis J. Reframing school dropout as a public health issue. Prev Chronic Dis. 2007 Oct;4(4):A107. Epub 2007 Sep 15.
Results Reference
background
PubMed Identifier
31071074
Citation
Petersen EE, Davis NL, Goodman D, Cox S, Mayes N, Johnston E, Syverson C, Seed K, Shapiro-Mendoza CK, Callaghan WM, Barfield W. Vital Signs: Pregnancy-Related Deaths, United States, 2011-2015, and Strategies for Prevention, 13 States, 2013-2017. MMWR Morb Mortal Wkly Rep. 2019 May 10;68(18):423-429. doi: 10.15585/mmwr.mm6818e1.
Results Reference
background
PubMed Identifier
32168209
Citation
Wang E, Glazer KB, Howell EA, Janevic TM. Social Determinants of Pregnancy-Related Mortality and Morbidity in the United States: A Systematic Review. Obstet Gynecol. 2020 Apr;135(4):896-915. doi: 10.1097/AOG.0000000000003762.
Results Reference
background
PubMed Identifier
27244844
Citation
Cheng TL, Johnson SB, Goodman E. Breaking the Intergenerational Cycle of Disadvantage: The Three Generation Approach. Pediatrics. 2016 Jun;137(6):e20152467. doi: 10.1542/peds.2015-2467. Epub 2016 May 9.
Results Reference
background
PubMed Identifier
25077268
Citation
National Research Council (US) and Institute of Medicine (US) Committee on Integrating the Science of Early Childhood Development; Shonkoff JP, Phillips DA, editors. From Neurons to Neighborhoods: The Science of Early Childhood Development. Washington (DC): National Academies Press (US); 2000. Available from http://www.ncbi.nlm.nih.gov/books/NBK225557/
Results Reference
background
PubMed Identifier
25821911
Citation
Noble KG, Houston SM, Brito NH, Bartsch H, Kan E, Kuperman JM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Murray SS, Casey BJ, Chang L, Ernst TM, Frazier JA, Gruen JR, Kennedy DN, Van Zijl P, Mostofsky S, Kaufmann WE, Kenet T, Dale AM, Jernigan TL, Sowell ER. Family income, parental education and brain structure in children and adolescents. Nat Neurosci. 2015 May;18(5):773-8. doi: 10.1038/nn.3983. Epub 2015 Mar 30.
Results Reference
background
PubMed Identifier
25828052
Citation
Noble KG, Engelhardt LE, Brito NH, Mack LJ, Nail EJ, Angal J, Barr R, Fifer WP, Elliott AJ; PASS Network. Socioeconomic disparities in neurocognitive development in the first two years of life. Dev Psychobiol. 2015 Jul;57(5):535-51. doi: 10.1002/dev.21303. Epub 2015 Mar 30.
Results Reference
background
PubMed Identifier
25249931
Citation
Brito NH, Noble KG. Socioeconomic status and structural brain development. Front Neurosci. 2014 Sep 4;8:276. doi: 10.3389/fnins.2014.00276. eCollection 2014.
Results Reference
background
PubMed Identifier
11752490
Citation
Bradley RH, Corwyn RF. Socioeconomic status and child development. Annu Rev Psychol. 2002;53:371-99. doi: 10.1146/annurev.psych.53.100901.135233.
Results Reference
background
PubMed Identifier
18020822
Citation
Duncan GJ, Dowsett CJ, Claessens A, Magnuson K, Huston AC, Klebanov P, Pagani LS, Feinstein L, Engel M, Brooks-Gunn J, Sexton H, Duckworth K, Japel C. School readiness and later achievement. Dev Psychol. 2007 Nov;43(6):1428-1446. doi: 10.1037/0012-1649.43.6.1428. Erratum In: Dev Psychol. 2008 Jan;44(1):232.
Results Reference
background
PubMed Identifier
16758315
Citation
Uchino BN. Social support and health: a review of physiological processes potentially underlying links to disease outcomes. J Behav Med. 2006 Aug;29(4):377-87. doi: 10.1007/s10865-006-9056-5. Epub 2006 Jun 7.
Results Reference
background
PubMed Identifier
15718937
Citation
Falk-Rafael A. Advancing nursing theory through theory-guided practice: the emergence of a critical caring perspective. ANS Adv Nurs Sci. 2005 Jan-Mar;28(1):38-49. doi: 10.1097/00012272-200501000-00005.
Results Reference
background
PubMed Identifier
3510017
Citation
Olds DL, Henderson CR Jr, Tatelbaum R, Chamberlin R. Improving the delivery of prenatal care and outcomes of pregnancy: a randomized trial of nurse home visitation. Pediatrics. 1986 Jan;77(1):16-28. Erratum In: Pediatrics 1986 Jul;78(1):138.
Results Reference
background
PubMed Identifier
2425334
Citation
Olds DL, Henderson CR Jr, Chamberlin R, Tatelbaum R. Preventing child abuse and neglect: a randomized trial of nurse home visitation. Pediatrics. 1986 Jul;78(1):65-78.
Results Reference
background
PubMed Identifier
3052116
Citation
Olds DL, Henderson CR Jr, Tatelbaum R, Chamberlin R. Improving the life-course development of socially disadvantaged mothers: a randomized trial of nurse home visitation. Am J Public Health. 1988 Nov;78(11):1436-45. doi: 10.2105/ajph.78.11.1436.
Results Reference
background
PubMed Identifier
9272895
Citation
Olds DL, Eckenrode J, Henderson CR Jr, Kitzman H, Powers J, Cole R, Sidora K, Morris P, Pettitt LM, Luckey D. Long-term effects of home visitation on maternal life course and child abuse and neglect. Fifteen-year follow-up of a randomized trial. JAMA. 1997 Aug 27;278(8):637-43.
Results Reference
background
PubMed Identifier
9786373
Citation
Olds D, Henderson CR Jr, Cole R, Eckenrode J, Kitzman H, Luckey D, Pettitt L, Sidora K, Morris P, Powers J. Long-term effects of nurse home visitation on children's criminal and antisocial behavior: 15-year follow-up of a randomized controlled trial. JAMA. 1998 Oct 14;280(14):1238-44. doi: 10.1001/jama.280.14.1238.
Results Reference
background
PubMed Identifier
9272896
Citation
Kitzman H, Olds DL, Henderson CR Jr, Hanks C, Cole R, Tatelbaum R, McConnochie KM, Sidora K, Luckey DW, Shaver D, Engelhardt K, James D, Barnard K. Effect of prenatal and infancy home visitation by nurses on pregnancy outcomes, childhood injuries, and repeated childbearing. A randomized controlled trial. JAMA. 1997 Aug 27;278(8):644-52.
Results Reference
background
PubMed Identifier
10789666
Citation
Kitzman H, Olds DL, Sidora K, Henderson CR Jr, Hanks C, Cole R, Luckey DW, Bondy J, Cole K, Glazner J. Enduring effects of nurse home visitation on maternal life course: a 3-year follow-up of a randomized trial. JAMA. 2000 Apr 19;283(15):1983-9. doi: 10.1001/jama.283.15.1983.
Results Reference
background
PubMed Identifier
15574614
Citation
Olds DL, Kitzman H, Cole R, Robinson J, Sidora K, Luckey DW, Henderson CR Jr, Hanks C, Bondy J, Holmberg J. Effects of nurse home-visiting on maternal life course and child development: age 6 follow-up results of a randomized trial. Pediatrics. 2004 Dec;114(6):1550-9. doi: 10.1542/peds.2004-0962.
Results Reference
background
PubMed Identifier
17908740
Citation
Olds DL, Kitzman H, Hanks C, Cole R, Anson E, Sidora-Arcoleo K, Luckey DW, Henderson CR Jr, Holmberg J, Tutt RA, Stevenson AJ, Bondy J. Effects of nurse home visiting on maternal and child functioning: age-9 follow-up of a randomized trial. Pediatrics. 2007 Oct;120(4):e832-45. doi: 10.1542/peds.2006-2111.
Results Reference
background
PubMed Identifier
20439792
Citation
Olds DL, Kitzman HJ, Cole RE, Hanks CA, Arcoleo KJ, Anson EA, Luckey DW, Knudtson MD, Henderson CR Jr, Bondy J, Stevenson AJ. Enduring effects of prenatal and infancy home visiting by nurses on maternal life course and government spending: follow-up of a randomized trial among children at age 12 years. Arch Pediatr Adolesc Med. 2010 May;164(5):419-24. doi: 10.1001/archpediatrics.2010.49.
Results Reference
background
PubMed Identifier
12205249
Citation
Olds DL, Robinson J, O'Brien R, Luckey DW, Pettitt LM, Henderson CR Jr, Ng RK, Sheff KL, Korfmacher J, Hiatt S, Talmi A. Home visiting by paraprofessionals and by nurses: a randomized, controlled trial. Pediatrics. 2002 Sep;110(3):486-96. doi: 10.1542/peds.110.3.486.
Results Reference
background
PubMed Identifier
15574615
Citation
Olds DL, Robinson J, Pettitt L, Luckey DW, Holmberg J, Ng RK, Isacks K, Sheff K, Henderson CR Jr. Effects of home visits by paraprofessionals and by nurses: age 4 follow-up results of a randomized trial. Pediatrics. 2004 Dec;114(6):1560-8. doi: 10.1542/peds.2004-0961.
Results Reference
background
PubMed Identifier
24296904
Citation
Olds DL, Holmberg JR, Donelan-McCall N, Luckey DW, Knudtson MD, Robinson J. Effects of home visits by paraprofessionals and by nurses on children: follow-up of a randomized trial at ages 6 and 9 years. JAMA Pediatr. 2014 Feb;168(2):114-21. doi: 10.1001/jamapediatrics.2013.3817.
Results Reference
background
PubMed Identifier
11128173
Citation
Fraser JA, Armstrong KL, Morris JP, Dadds MR. Home visiting intervention for vulnerable families with newborns: follow-up results of a randomized controlled trial. Child Abuse Negl. 2000 Nov;24(11):1399-429. doi: 10.1016/s0145-2134(00)00193-9.
Results Reference
background
PubMed Identifier
23660409
Citation
Alonso-Marsden S, Dodge KA, O'Donnell KJ, Murphy RA, Sato JM, Christopoulos C. Family risk as a predictor of initial engagement and follow-through in a universal nurse home visiting program to prevent child maltreatment. Child Abuse Negl. 2013 Aug;37(8):555-65. doi: 10.1016/j.chiabu.2013.03.012. Epub 2013 May 6.
Results Reference
background
PubMed Identifier
17822764
Citation
Duggan A, Caldera D, Rodriguez K, Burrell L, Rohde C, Crowne SS. Impact of a statewide home visiting program to prevent child abuse. Child Abuse Negl. 2007 Aug;31(8):801-27. doi: 10.1016/j.chiabu.2006.06.011. Epub 2007 Sep 5.
Results Reference
background
PubMed Identifier
18377991
Citation
DuMont K, Mitchell-Herzfeld S, Greene R, Lee E, Lowenfels A, Rodriguez M, Dorabawila V. Healthy Families New York (HFNY) randomized trial: effects on early child abuse and neglect. Child Abuse Negl. 2008 Mar;32(3):295-315. doi: 10.1016/j.chiabu.2007.07.007.
Results Reference
background
PubMed Identifier
7148988
Citation
Bowlby J. Attachment and loss: retrospect and prospect. Am J Orthopsychiatry. 1982 Oct;52(4):664-678. doi: 10.1111/j.1939-0025.1982.tb01456.x. No abstract available.
Results Reference
background
PubMed Identifier
24637261
Citation
Swain JE, Kim P, Spicer J, Ho SS, Dayton CJ, Elmadih A, Abel KM. Approaching the biology of human parental attachment: brain imaging, oxytocin and coordinated assessments of mothers and fathers. Brain Res. 2014 Sep 11;1580:78-101. doi: 10.1016/j.brainres.2014.03.007. Epub 2014 Mar 15.
Results Reference
background
PubMed Identifier
16008790
Citation
Evans GW, Gonnella C, Marcynyszyn LA, Gentile L, Salpekar N. The role of chaos in poverty and children's socioemotional adjustment. Psychol Sci. 2005 Jul;16(7):560-5. doi: 10.1111/j.0956-7976.2005.01575.x.
Results Reference
background
PubMed Identifier
26076883
Citation
Miller TR. Projected Outcomes of Nurse-Family Partnership Home Visitation During 1996-2013, USA. Prev Sci. 2015 Aug;16(6):765-77. doi: 10.1007/s11121-015-0572-9.
Results Reference
background
Links:
URL
https://www.brookings.edu/blog/up-front/2020/02/27/examining-the-black-white-wealth-gap/.
Description
McIntosh K, Moss, E., Nunn, R., and Shambaugh, J. Examining the Black-white wealth gap. The Brookings Institute. https://www.brookings.edu/blog/up-front/2020/02/27/examining-the-black-white-wealth-gap/. Published 2020. Accessed2020.
URL
https://socialequity.duke.edu/wp-content/uploads/2019/10/what-we-get-wrong.pdf
Description
Darity Jr. W, Hamilton, D., Paul, M., Aja, A., Price, A., Moore, A., and Chiopris, C. What We Get Wrong About Closing the Racial Wealth Gap. Samuel DuBois Cook Center on Social Equality, Insight Center for Community Economic Development.
URL
https://www.aft.org/ae/spring2003/hart_risley
Description
Hart B, Risley TR. The early catastrophe. EDUCATION REVIEW-LONDON-. 2003;17(1):110-118.
URL
https://evidencebasedprograms.org/policy_area/prenatal-earlychildhood
Description
Nurse-Family Partnership: A nurse home visitation program for low-income, pregnant women. Social Programs that Work. Prenatal/Early Childhood. . https://evidencebasedprograms.org/policy_area/prenatal-earlychildhood/. Published 2019. Accessed 6/12/2019.
URL
https://homvee.acf.hhs.gov/
Description
Effectiveness HVEo. What is Home Visiting Evidence of Effectiveness? U.S. Department of Health and Human Serivces: Administration for Children and Families. https://homvee.acf.hhs.gov/. Published 2020. Accessed2020.
URL
https://www.brookings.edu/wp-content/uploads/2016/06/1001_social_science_haskins.pdf
Description
Haskins R, Paxson, C., Brooks-Gunn, J. Social Science Rising: A Tale of Evidence Shaping Public Policy. Princeton, Brookings. ;2009.

Learn more about this trial

Nurse Family Partnership for Women With Previous Live Births

We'll reach out to this number within 24 hrs