Candin for the Treatment of Common Warts
Common Warts (Verruca Vulgaris)
About this trial
This is an interventional treatment trial for Common Warts (Verruca Vulgaris) focused on measuring Common wart, Intralesional injection, Candida albicans, Immunotherapy
Eligibility Criteria
Inclusion Criteria: At least 3, but not more than 20 common warts (Verruca vulgaris) Willing to agree to use adequate contraception methods during the study Exclusion Criteria: Systemic or localized diseases, conditions, or medications that could interfere with the assessment of safety or efficacy or that compromise immune function Candin delayed type hypersensitivity reaction test wheal sized < 5 mm or > 25 mm at the Baseline Visit History of keloid formation Prior treatment of common warts with liquid nitrogen, carbon dioxide, electrodesiccation, laser, surgery, salicylic acid, etc., that, in the Investigator's opinion, does not exhibit complete healing from the treatment Treatment with immunotherapy (e.g., diphenylcyclopropenone [DPCP], dinitrochlorobenzene [DNCB], or other), imiquimod, 5-fluorouracil, bleomycin, or podophyllin within 12 weeks of the Baseline Visit or during the study Prior treatment with Candida albicans within 12 weeks of the Baseline Visit or during the study Systemic treatment with an immunosuppressive drug during the study or in the 6 months or 5 half lives prior to the Baseline Visit or during the study (e.g., azathioprine, 6 mercaptopurine, methotrexate, infliximab, adalimumab, etanercept, systemic steroids [topical or inhaled steroids are acceptable]). Use of cantharidin or an investigational agent or device within the 30 days prior to the Baseline Visit or during the study
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Candin treatment
Placebo
Candida albicans Skin Test Antigen for Cellular Hypersensitivity will be administered as a 0.5 mL injection at the region of the interdigitated base of the treatment wart (epidermal/dermal junction) every 2 weeks for up to 10 injections
Matching placebo (sterile saline) will be administered as a 0.5 mL injection at the region of the interdigitated base of the treatment wart (epidermal/dermal junction) every 2 weeks for up to 10 injections