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Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post Covid Syndrome (YoFaPoCo)

Primary Purpose

Post-COVID-19 Syndrome, Fatigue Post Viral

Status
Not yet recruiting
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Yoga Therapy
Health Education
Sponsored by
University Hospital Tuebingen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Post-COVID-19 Syndrome focused on measuring Fatigue, Covid

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Confirmed COVID-19 diagnosis Follow-up symptoms of ≥ 12 weeks Persistent fatigue (scores ≥4 on the binomial Chalder Fatigue Scale). Self-assessment that fatigue was a consequence of COVID-19 disease Age 18-65 years Exclusion Criteria: Chronic medical conditions or regular use of medications associated with fatigue Indication of health cause of fatigue other than post-COVID. Indication of other factors as the main cause of fatigue Physical limitations that do not allow participation in the yoga intervention Pregnancy, breastfeeding Concurrent participation in other clinical trials Current yoga practice

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Experimental

    Active Comparator

    Arm Label

    Yoga Therapy

    Health Education

    Arm Description

    12 week yoga program, one weekly session of 90 minutes each, plus 2 times weekly 30 minutes of self practice.

    12 week health education program, one weekly session of 90 minutes each, plus 2 times weekly 30 minutes of self practice.

    Outcomes

    Primary Outcome Measures

    Fatigue
    The chalder fatigue scale is used to assess the severity of fatigue within the last 4 weeks. It contains 11 questions in a four-step answer format (0-4), 7 of which refer to the degree of physical fatigue and 4 to the degree of mental fatigue. In its binomial evaluation (range 0-11) it can be used with a cut-off of (≥ 4) to divide patients into those with and those without fatigue.

    Secondary Outcome Measures

    Fatigue
    Chalder Fatigue Scale
    Health related quality of life SF-12
    Short Form 12 Health Survey Questionnaire, The SF-12 represents the most commonly used instrument in clinical trials to assess generic quality of life. The questionnaire captures 8 different subscales, which are combined into a physical and a psychological summated scale.
    Health related quality of life SF-12
    Short Form 12 Health Survey Questionnaire, The SF-12 represents the most commonly used instrument in clinical trials to assess generic quality of life. The questionnaire captures 8 different subscales, which are combined into a physical and a psychological summated scale.
    Health related quality of life EQ-5D-5L
    The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. In this study, the EQ-5D-5L is used for cost-effectiveness analysis, together with healthcare-related costs.
    Health related quality of life EQ-5D-5L
    The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. In this study, the EQ-5D-5L is used for cost-effectiveness analysis, together with healthcare-related costs.
    Psychological symptoms
    The Hospital Anxiety and Depression Scale asks 14 questions, of which 7 are about anxiety and 7 about depression in patients with physical illnesses and physical complaints. More precisely, it measures the self-assessed severity of patients' anxious and depressive symptoms in relation to the past week.
    Psychological symptoms
    The Hospital Anxiety and Depression Scale asks 14 questions, of which 7 are about anxiety and 7 about depression in patients with physical illnesses and physical complaints. More precisely, it measures the self-assessed severity of patients' anxious and depressive symptoms in relation to the past week.
    Sleep quality
    The Pittsburgh Sleep Quality Index (PSQI) assesses the quality of sleep over the past 4 weeks using 24 questions, 17 for self-assessment and 7 for external assessment. It is used clinically to monitor patients with sleep disorders and to screen for sleep disorders in epidemiological studies.
    Sleep quality
    The Pittsburgh Sleep Quality Index (PSQI) assesses the quality of sleep over the past 4 weeks using 24 questions, 17 for self-assessment and 7 for external assessment. It is used clinically to monitor patients with sleep disorders and to screen for sleep disorders in epidemiological studies.
    Stress
    The current stress perception of the patients is assessed by means of the Perceived Stress Scale (PSS-10). This measures the current subjective perceived stress of the patients on the basis of 10 items.
    Stress
    The current stress perception of the patients is assessed by means of the Perceived Stress Scale (PSS-10). This measures the current subjective perceived stress of the patients on the basis of 10 items.
    Post-exertional malaise
    Post-exertional malaise (PEM) is a delayed worsening of symptoms that occurs after minimal physical or mental activity. The DePaul-Symptom Questionaire (DSQ) is used to asses PEM.
    Post-exertional malaise
    Post-exertional malaise (PEM) is a delayed worsening of symptoms that occurs after minimal physical or mental activity. The DePaul-Symptom Questionaire (DSQ) is used to asses PEM.
    Body awareness
    The BAQ is an 18-item scale designed to assess self-reported attentiveness to normal nonemotive body processes, specifically, sensitivity to body cycles and rhythms, ability to detect small changes in normal functioning, and ability to anticipate bodily reactions. Body awareness will be used in mediation analyses of treatment effects.
    Body awareness
    The BAQ is an 18-item scale designed to assess self-reported attentiveness to normal nonemotive body processes, specifically, sensitivity to body cycles and rhythms, ability to detect small changes in normal functioning, and ability to anticipate bodily reactions. Body awareness will be used in mediation analyses of treatment effects.
    Self-Efficacy
    The Arthritis Self-Efficacy Scale (ASES) was originally developed in 1989 as part of the Stanford Arthritis Self-Management Study to assess self-efficacy in arthritis patients and has since been used to assess it in many disease conditions. A short version (ASES-8/ASES-D) has been validated. This version surveys in scale level 1-10 the perceived ability to deal with occurring symptoms such as: Pain or fatigue. Self-efficacy will be used in mediation analyses of treatment effects.
    Self-Efficacy
    The Arthritis Self-Efficacy Scale (ASES) was originally developed in 1989 as part of the Stanford Arthritis Self-Management Study to assess self-efficacy in arthritis patients and has since been used to assess it in many disease conditions. A short version (ASES-8/ASES-D) has been validated. This version surveys in scale level 1-10 the perceived ability to deal with occurring symptoms such as: Pain or fatigue. Self-efficacy will be used in mediation analyses of treatment effects.
    Adverse events
    Adverse events and serious adverse events are documented. Adverse events include any adverse symptoms, illnesses, disorders, or accidents that occur during the course of the study. Serious adverse events include events occurring during the course of the study that are immediately life-threatening and/or result in serious health problems (specifically, requiring unanticipated hospitalization or prolongation of hospitalization, or resulting in serious disability or incapacitation). The severity as well as the possible causal relationship with the intervention will be assessed by the study physician.
    Adverse events
    Adverse events and serious adverse events are documented. Adverse events include any adverse symptoms, illnesses, disorders, or accidents that occur during the course of the study. Serious adverse events include events occurring during the course of the study that are immediately life-threatening and/or result in serious health problems (specifically, requiring unanticipated hospitalization or prolongation of hospitalization, or resulting in serious disability or incapacitation). The severity as well as the possible causal relationship with the intervention will be assessed by the study physician.
    C-reactive proteine
    CRP as marker of pro-inflammatory cytokine activity, from blood samples.
    C-reactive proteine
    CRP as marker of pro-inflammatory cytokine activity, from blood samples.
    Interleukine-6
    IL-6, as marker of pro-inflammatory cytokine activity, from blood samples.
    Interleukine-6
    IL-6, as marker of pro-inflammatory cytokine activity, from blood samples.
    D-dimer
    D-dimer, as a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample
    D-dimer
    D-dimer, as a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample
    Lactate dehydrogenase
    Lactate dehydrogenase (LDH), measuring the amount of LDH in the blood. Lactate dehydrogenase is an enzyme that the body uses during the process of turning sugar into energy for your cells to use.
    Lactate dehydrogenase
    Lactate dehydrogenase (LDH), measuring the amount of LDH in the blood. Lactate dehydrogenase is an enzyme that the body uses during the process of turning sugar into energy for your cells to use.
    Leukocytes and lymphocytes
    Leukocytes and lymphocytes, from blood samples.
    Leukocytes and lymphocytes
    Leukocytes and lymphocytes, from blood samples.
    Grip strength
    Repeated measurement of hand strength can help detect physical decline and inflammatory processes Hand strength measurement can be an invaluable tool for monitoring physical performance decline.
    Grip strength
    Repeated measurement of hand strength can help detect physical decline and inflammatory processes Hand strength measurement can be an invaluable tool for monitoring physical performance decline.
    Movement tracking
    General tracking of patients' movement habits via activity monitor
    Movement tracking
    General tracking of patients' movement habits via activity monitor
    Heart rate variability
    HRV is simply a measure of the variation in time between each heartbeat. This variation is controlled by a primitive part of the nervous system called the autonomic nervous system (ANS). It works behind the scenes, automatically regulating our heart rate, blood pressure, breathing, and digestion among other key tasks.
    Heart rate variability
    HRV is simply a measure of the variation in time between each heartbeat. This variation is controlled by a primitive part of the nervous system called the autonomic nervous system (ANS). It works behind the scenes, automatically regulating our heart rate, blood pressure, breathing, and digestion among other key tasks.

    Full Information

    First Posted
    June 2, 2023
    Last Updated
    June 2, 2023
    Sponsor
    University Hospital Tuebingen
    Collaborators
    Robert Bosch Gesellschaft für Medizinische Forschung mbH, Charite University, Berlin, Germany
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    1. Study Identification

    Unique Protocol Identification Number
    NCT05890599
    Brief Title
    Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post Covid Syndrome
    Acronym
    YoFaPoCo
    Official Title
    Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post Covid Syndrome
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    January 2023
    Overall Recruitment Status
    Not yet recruiting
    Study Start Date
    June 2023 (Anticipated)
    Primary Completion Date
    May 2024 (Anticipated)
    Study Completion Date
    August 2024 (Anticipated)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Sponsor
    Name of the Sponsor
    University Hospital Tuebingen
    Collaborators
    Robert Bosch Gesellschaft für Medizinische Forschung mbH, Charite University, Berlin, Germany

    4. Oversight

    Studies a U.S. FDA-regulated Drug Product
    No
    Studies a U.S. FDA-regulated Device Product
    No
    Data Monitoring Committee
    Yes

    5. Study Description

    Brief Summary
    Evaluation of the short- and medium-term effect of a yoga intervention in addition to routine care compared to health education in addition to routine care on fatigue in patients with post covid syndrome.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Post-COVID-19 Syndrome, Fatigue Post Viral
    Keywords
    Fatigue, Covid

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Not Applicable
    Interventional Study Model
    Parallel Assignment
    Masking
    Outcomes Assessor
    Allocation
    Randomized
    Enrollment
    100 (Anticipated)

    8. Arms, Groups, and Interventions

    Arm Title
    Yoga Therapy
    Arm Type
    Experimental
    Arm Description
    12 week yoga program, one weekly session of 90 minutes each, plus 2 times weekly 30 minutes of self practice.
    Arm Title
    Health Education
    Arm Type
    Active Comparator
    Arm Description
    12 week health education program, one weekly session of 90 minutes each, plus 2 times weekly 30 minutes of self practice.
    Intervention Type
    Behavioral
    Intervention Name(s)
    Yoga Therapy
    Intervention Description
    The range of interventions is based on previous studies on yoga interventions specifically for fatigue patients as well as on recommendations, for example, from the WHO. The yoga therapy includes 3 elements: yoga postures (asanas), breathing techniques (pranayama) and relaxation moments. Emphasis on postures and breathing techniques that are considered to be effective for fatigue symptoms, as well as specific breathing exercises to strengthen the respiratory muscles and increase lung volume.
    Intervention Type
    Behavioral
    Intervention Name(s)
    Health Education
    Intervention Description
    Health education courses are conducted on-site once a week for 90 minutes over 12 weeks by a psychologist with clinical experience. The courses are didactic in nature and consist of lectures on topics of interest to patients with post-COVID syndrome and fatigue, followed by questions and discussion sessions. Topics include information on post-COVID syndrome and fatigue, an introduction to self-help for post-viral symptoms, psychosocial problems and fatigue, relaxation and stress management, nutrition, sleep hygiene, exercise, respecting one's own limits, acceptance, finding meaning, and achieving goals.
    Primary Outcome Measure Information:
    Title
    Fatigue
    Description
    The chalder fatigue scale is used to assess the severity of fatigue within the last 4 weeks. It contains 11 questions in a four-step answer format (0-4), 7 of which refer to the degree of physical fatigue and 4 to the degree of mental fatigue. In its binomial evaluation (range 0-11) it can be used with a cut-off of (≥ 4) to divide patients into those with and those without fatigue.
    Time Frame
    12 weeks
    Secondary Outcome Measure Information:
    Title
    Fatigue
    Description
    Chalder Fatigue Scale
    Time Frame
    24 weeks
    Title
    Health related quality of life SF-12
    Description
    Short Form 12 Health Survey Questionnaire, The SF-12 represents the most commonly used instrument in clinical trials to assess generic quality of life. The questionnaire captures 8 different subscales, which are combined into a physical and a psychological summated scale.
    Time Frame
    12 weeks
    Title
    Health related quality of life SF-12
    Description
    Short Form 12 Health Survey Questionnaire, The SF-12 represents the most commonly used instrument in clinical trials to assess generic quality of life. The questionnaire captures 8 different subscales, which are combined into a physical and a psychological summated scale.
    Time Frame
    24 weeks
    Title
    Health related quality of life EQ-5D-5L
    Description
    The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. In this study, the EQ-5D-5L is used for cost-effectiveness analysis, together with healthcare-related costs.
    Time Frame
    12 weeks
    Title
    Health related quality of life EQ-5D-5L
    Description
    The EQ-5D-5L is a self-assessed, health related, quality of life questionnaire. The scale measures quality of life on a 5-component scale including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. In this study, the EQ-5D-5L is used for cost-effectiveness analysis, together with healthcare-related costs.
    Time Frame
    24 weeks
    Title
    Psychological symptoms
    Description
    The Hospital Anxiety and Depression Scale asks 14 questions, of which 7 are about anxiety and 7 about depression in patients with physical illnesses and physical complaints. More precisely, it measures the self-assessed severity of patients' anxious and depressive symptoms in relation to the past week.
    Time Frame
    12 weeks
    Title
    Psychological symptoms
    Description
    The Hospital Anxiety and Depression Scale asks 14 questions, of which 7 are about anxiety and 7 about depression in patients with physical illnesses and physical complaints. More precisely, it measures the self-assessed severity of patients' anxious and depressive symptoms in relation to the past week.
    Time Frame
    24 weeks
    Title
    Sleep quality
    Description
    The Pittsburgh Sleep Quality Index (PSQI) assesses the quality of sleep over the past 4 weeks using 24 questions, 17 for self-assessment and 7 for external assessment. It is used clinically to monitor patients with sleep disorders and to screen for sleep disorders in epidemiological studies.
    Time Frame
    12 weeks
    Title
    Sleep quality
    Description
    The Pittsburgh Sleep Quality Index (PSQI) assesses the quality of sleep over the past 4 weeks using 24 questions, 17 for self-assessment and 7 for external assessment. It is used clinically to monitor patients with sleep disorders and to screen for sleep disorders in epidemiological studies.
    Time Frame
    24 weeks
    Title
    Stress
    Description
    The current stress perception of the patients is assessed by means of the Perceived Stress Scale (PSS-10). This measures the current subjective perceived stress of the patients on the basis of 10 items.
    Time Frame
    12 weeks
    Title
    Stress
    Description
    The current stress perception of the patients is assessed by means of the Perceived Stress Scale (PSS-10). This measures the current subjective perceived stress of the patients on the basis of 10 items.
    Time Frame
    24 weeks
    Title
    Post-exertional malaise
    Description
    Post-exertional malaise (PEM) is a delayed worsening of symptoms that occurs after minimal physical or mental activity. The DePaul-Symptom Questionaire (DSQ) is used to asses PEM.
    Time Frame
    12 weeks
    Title
    Post-exertional malaise
    Description
    Post-exertional malaise (PEM) is a delayed worsening of symptoms that occurs after minimal physical or mental activity. The DePaul-Symptom Questionaire (DSQ) is used to asses PEM.
    Time Frame
    24 weeks
    Title
    Body awareness
    Description
    The BAQ is an 18-item scale designed to assess self-reported attentiveness to normal nonemotive body processes, specifically, sensitivity to body cycles and rhythms, ability to detect small changes in normal functioning, and ability to anticipate bodily reactions. Body awareness will be used in mediation analyses of treatment effects.
    Time Frame
    12 weeks
    Title
    Body awareness
    Description
    The BAQ is an 18-item scale designed to assess self-reported attentiveness to normal nonemotive body processes, specifically, sensitivity to body cycles and rhythms, ability to detect small changes in normal functioning, and ability to anticipate bodily reactions. Body awareness will be used in mediation analyses of treatment effects.
    Time Frame
    24 weeks
    Title
    Self-Efficacy
    Description
    The Arthritis Self-Efficacy Scale (ASES) was originally developed in 1989 as part of the Stanford Arthritis Self-Management Study to assess self-efficacy in arthritis patients and has since been used to assess it in many disease conditions. A short version (ASES-8/ASES-D) has been validated. This version surveys in scale level 1-10 the perceived ability to deal with occurring symptoms such as: Pain or fatigue. Self-efficacy will be used in mediation analyses of treatment effects.
    Time Frame
    12 weeks
    Title
    Self-Efficacy
    Description
    The Arthritis Self-Efficacy Scale (ASES) was originally developed in 1989 as part of the Stanford Arthritis Self-Management Study to assess self-efficacy in arthritis patients and has since been used to assess it in many disease conditions. A short version (ASES-8/ASES-D) has been validated. This version surveys in scale level 1-10 the perceived ability to deal with occurring symptoms such as: Pain or fatigue. Self-efficacy will be used in mediation analyses of treatment effects.
    Time Frame
    24 weeks
    Title
    Adverse events
    Description
    Adverse events and serious adverse events are documented. Adverse events include any adverse symptoms, illnesses, disorders, or accidents that occur during the course of the study. Serious adverse events include events occurring during the course of the study that are immediately life-threatening and/or result in serious health problems (specifically, requiring unanticipated hospitalization or prolongation of hospitalization, or resulting in serious disability or incapacitation). The severity as well as the possible causal relationship with the intervention will be assessed by the study physician.
    Time Frame
    12 weeks
    Title
    Adverse events
    Description
    Adverse events and serious adverse events are documented. Adverse events include any adverse symptoms, illnesses, disorders, or accidents that occur during the course of the study. Serious adverse events include events occurring during the course of the study that are immediately life-threatening and/or result in serious health problems (specifically, requiring unanticipated hospitalization or prolongation of hospitalization, or resulting in serious disability or incapacitation). The severity as well as the possible causal relationship with the intervention will be assessed by the study physician.
    Time Frame
    24 weeks
    Title
    C-reactive proteine
    Description
    CRP as marker of pro-inflammatory cytokine activity, from blood samples.
    Time Frame
    12 weeks
    Title
    C-reactive proteine
    Description
    CRP as marker of pro-inflammatory cytokine activity, from blood samples.
    Time Frame
    24 weeks
    Title
    Interleukine-6
    Description
    IL-6, as marker of pro-inflammatory cytokine activity, from blood samples.
    Time Frame
    12 weeks
    Title
    Interleukine-6
    Description
    IL-6, as marker of pro-inflammatory cytokine activity, from blood samples.
    Time Frame
    24 weeks
    Title
    D-dimer
    Description
    D-dimer, as a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample
    Time Frame
    12 weeks
    Title
    D-dimer
    Description
    D-dimer, as a by-product of the blood clotting and break-down process that can be measured via analysis of a blood sample
    Time Frame
    24 weeks
    Title
    Lactate dehydrogenase
    Description
    Lactate dehydrogenase (LDH), measuring the amount of LDH in the blood. Lactate dehydrogenase is an enzyme that the body uses during the process of turning sugar into energy for your cells to use.
    Time Frame
    12 weeks
    Title
    Lactate dehydrogenase
    Description
    Lactate dehydrogenase (LDH), measuring the amount of LDH in the blood. Lactate dehydrogenase is an enzyme that the body uses during the process of turning sugar into energy for your cells to use.
    Time Frame
    24 weeks
    Title
    Leukocytes and lymphocytes
    Description
    Leukocytes and lymphocytes, from blood samples.
    Time Frame
    12 weeks
    Title
    Leukocytes and lymphocytes
    Description
    Leukocytes and lymphocytes, from blood samples.
    Time Frame
    24 weeks
    Title
    Grip strength
    Description
    Repeated measurement of hand strength can help detect physical decline and inflammatory processes Hand strength measurement can be an invaluable tool for monitoring physical performance decline.
    Time Frame
    12 weeks
    Title
    Grip strength
    Description
    Repeated measurement of hand strength can help detect physical decline and inflammatory processes Hand strength measurement can be an invaluable tool for monitoring physical performance decline.
    Time Frame
    24 weeks
    Title
    Movement tracking
    Description
    General tracking of patients' movement habits via activity monitor
    Time Frame
    12 weeks
    Title
    Movement tracking
    Description
    General tracking of patients' movement habits via activity monitor
    Time Frame
    24 weeks
    Title
    Heart rate variability
    Description
    HRV is simply a measure of the variation in time between each heartbeat. This variation is controlled by a primitive part of the nervous system called the autonomic nervous system (ANS). It works behind the scenes, automatically regulating our heart rate, blood pressure, breathing, and digestion among other key tasks.
    Time Frame
    12 weeks
    Title
    Heart rate variability
    Description
    HRV is simply a measure of the variation in time between each heartbeat. This variation is controlled by a primitive part of the nervous system called the autonomic nervous system (ANS). It works behind the scenes, automatically regulating our heart rate, blood pressure, breathing, and digestion among other key tasks.
    Time Frame
    24 weeks
    Other Pre-specified Outcome Measures:
    Title
    Therapy rationale and therapy expectancy
    Description
    The Credibility Expectancy Questionnaire (CEQ) published by Ametrano, et al. 2011 and validated as German version by Rieke, et al. 2013 is used to measure Therapierationale and Therapieerwartung at baseline. It measures these over 6 items using 9-point Likert scales.
    Time Frame
    Week 1
    Title
    Personality dimensions
    Description
    Big-Five-Inventory-10 (BFI-10) is used to assess personality dimensions based on the big-5 model.
    Time Frame
    Week 1

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    18 Years
    Maximum Age & Unit of Time
    65 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: Confirmed COVID-19 diagnosis Follow-up symptoms of ≥ 12 weeks Persistent fatigue (scores ≥4 on the binomial Chalder Fatigue Scale). Self-assessment that fatigue was a consequence of COVID-19 disease Age 18-65 years Exclusion Criteria: Chronic medical conditions or regular use of medications associated with fatigue Indication of health cause of fatigue other than post-COVID. Indication of other factors as the main cause of fatigue Physical limitations that do not allow participation in the yoga intervention Pregnancy, breastfeeding Concurrent participation in other clinical trials Current yoga practice
    Central Contact Person:
    First Name & Middle Initial & Last Name or Official Title & Degree
    Holger Cramer, Professor
    Phone
    +49 711 8101 7858
    Email
    yasemin.anguelov@bosch-health-campus.com

    12. IPD Sharing Statement

    Learn more about this trial

    Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post Covid Syndrome

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