Watermelon Dose Response Blood Pressure Study (WMBP)
Pre-hypertension, Cardiovascular Diseases
About this trial
This is an interventional prevention trial for Pre-hypertension focused on measuring Watermelon, Blood pressure, Pre-hypertension
Eligibility Criteria
Inclusion Criteria: Individuals who are nonsmokers Healthy overweight/ obese man or woman between 25 and 65 years of age Blood pressure 120-160 mmHg systolic or 80-100 mm/Hg diastolic at screening visit Fasting blood glucose concentration between 100 mg/dL and 125 mg/dL at screening visit (value range indicate prediabetes, by finger prick and/or venous blood sampling) Have no clinical evidence/history of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease Exclusion Criteria: Smoker Vegetarian Men and women who have fasting blood glucose concentration <100 or >125 mg/dL at screening visit Uncontrolled blood pressure ≥140 mmHg (systolic)/ ≥ 90 mmHg (diastolic) Over the counter supplements (e.g. fiber supplements, probiotics and/or prebiotics, antioxidants, anti-inflammation) Dietary supplements like (garlic, fish oil), glutamine supplements, grape seed extract, L-citrulline/arginine Cholesterol-lowering medications, anticoagulants, blood pressure-lowering medications,) and/or taking prescription medications that may interfere with study procedures or endpoints (e.g. gastrointestinal medications, antibiotics) within the last 30 days Have cancer other than non-melanoma skin cancer in previous 5 years Taking unstable dose of hormonal contraceptive and/or a stable dose less than 6 months Planning to become pregnant, pregnant and/or breast-feeding Excessive exerciser or a trained athlete Drink excessive amount of coffee/tea (> 5 cups per day) Donated blood within last 3 months Have allergies/intolerances to foods consumed in the study Currently eat > 2 servings of watermelons per day Actively losing weight/ trying to lose weight (unstable body weight fluctuations of > 11 lbs in 3 months) Addicted to drugs or alcohol Have significant psychiatric or neurological disturbances that may interfere with the ability to follow the study protocol
Sites / Locations
- Clinical Nutrition Research CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Active Comparator
Control
Watermelon flesh Dose 1
Watermelon flesh Dose 2
Calorie-matched control beverage
1 cup watermelon flesh, ~152 g
2 cups watermelon flesh, ~304 g