Study and Transformation of Tumor Molecular Features Screening Model of Endometrial Carcinoma Surgical Approach
Endometrial Carcinoma, Tumor Molecular Features Screening Model
About this trial
This is an interventional treatment trial for Endometrial Carcinoma
Eligibility Criteria
Inclusion Criteria: Women aged 40-80 years. Preoperative hysteroscopic biopsy pathology is endometrial carcinoma, preoperative imaging evaluation of tumor limited to uterine or extrauterine metastasis limited to pelvic or para-aortic lymph nodes. No liver and kidney function abnormalities and bone marrow suppression before surgery. ECOG score 0 points. Subjects voluntarily joined the study, signed an informed consent form, had good compliance, and cooperated with follow-up. Molecular testing has confirmed that the participant does not have high mutational burden characteristics (including POLE mutations, MSI-H, homologous recombinant repair pathway mutations). Exclusion Criteria: Preoperative adjuvant therapy. Have contraindications to chemoradiotherapy and cannot receive postoperative adjuvant chemoradiotherapy. Previous history of other malignant tumors or other malignant tumors at the same time. Laparoscopic surgery transferred to open surgery for special reasons. unable or unwilling to comply with the requirements of the study.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
open surgery group
laparoscopic surgery group
Patients who met the inclusion criteria and excluded the exclusion criteria, and did not have high mutational burden characteristics after molecular testing, were randomly divided into open surgery group or laparoscopic surgery group according to 1:1.
Patients who met the inclusion criteria and excluded the exclusion criteria, and did not have high mutational burden characteristics after molecular testing, were randomly divided into open surgery group or laparoscopic surgery group according to 1:1.