A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma.
Diffuse Large B-Cell Lymphoma
About this trial
This is an interventional treatment trial for Diffuse Large B-Cell Lymphoma focused on measuring DLBCL, Lymphoma, Relapsed, Refractory, CD20, CD3, CD47, Glofitamab, Obinutuzumab, Maplirpacept
Eligibility Criteria
Key Inclusion Criteria: Histologically confirmed diagnosis of DLBCL Relapsed or refractory disease Participant is not be a candidate for or is unwilling to undergo high dose chemotherapy and subsequent stem cell transplant and/or is unable to receive chimeric antigen receptor (CAR) T-cell therapy Previous treatment with at least one prior line of systemic therapy (for phase 2, at least 1 and no more than 2 prior lines of systemic therapy). Prior therapy must include an anti-CD20 antibody. Adequate bone marrow, hepatic and renal function Eastern Cooperative Oncology Group (ECOG) ≤2 Key Exclusion Criteria: Prior treatment with anti-CD47 and/or prior glofitamab or anti-CD20 x CD3 containing regimen. Refractoriness to an obinutuzumab monotherapy containing regimen. Prior allogeneic stem cell transplantation or autologous stem cell transplantation within 12 weeks prior to enrolment High Grade B-Cell Lymphoma Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection.
Sites / Locations
- Allina Health Cancer Institute - Abbott Northwestern Hospital
- Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
- Shizuoka Cancer CenterRecruiting
- National Hospital Organization Kyushu Cancer CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Phase 1b
Phase 2
Participants will be allocated to sequential dose levels of PF-07901801, administered in combination with fixed doses of glofitamab after a dose of obinutuzumab, to select two doses of PF-07901801 for further evaluation in Phase 2. Approximately 20 participants will be enrolled.
Participants will be randomized to 1 of 2 different dose levels of PF-07901801 which will be administered in combination with fixed doses of glofitamab after a dose of obinutuzumab. Approximately 50 participants will be enrolled (25 per dose).