Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
Breast Cancer, Cognitive Impairments
About this trial
This is an interventional prevention trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria: The participant must provide study-specific informed consent prior to any study specific procedures and authorization permitting release of personal health information. The participant must have a first time diagnosis of non-metastatic breast cancer which is Stage I-III. The participant must have a score of less than 12 on the PROMIS Adult v2.0 - Cognitive Function 4a. Participants with greater than or equal to 6 months to 5 years post-treatment (completion of initial surgery +/- adjuvant chemotherapy/radiation therapy) except may still be taking endocrine therapy or HER2-directed adjuvant therapy. The participant must be able to understand, speak, read, and write in English or Spanish. Exclusion Criteria: Scoring less than or equal to 3 on the 6-item cognitive screen. Patient Health Questionnaire-2 item (PHQ-2) score of greater than or equal to 3. Definitive clinical or radiologic evidence of metastatic disease. Prior history of past or current other cancer, except for non-melanoma skin cancer or in situ cervical cancer within the past 5 years. Previous exposure to chemotherapy treatment for another cancer or due to other medical condition (e.g. methotrexate exposure for treatment of rheumatoid arthritis). Previous central nervous system (CNS) radiation, intrathecal therapy or CNS-involved surgery. Participants with history of stroke, traumatic brain injury, brain surgery, Alzheimer's disease or other dementia. Participants with active substance abuse and/or in treatment for substance abuse, or history of bipolar disorder, psychosis, schizophrenia, ADHD, or learning disability.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Arm 1: Attention Control
Arm 2: Computerized Cognitive Training (BrainHQ)
The computerized active attention control intervention is composed of computerized games. The computerized active attention control games are fully developed and are rated E (for everyone) by the Entertainment Software Rating Board. The program will present 8 non-speeded exercises that include spin-offs of such games as breaking hex, lineup four, battleship, gems swap, double klondike, solitaire, reversi, word search, and sudoku.
BrainHQ provides core elements necessary for inducing neuroplasticity. The five core elements include the principles of speed of processing, accuracy of processing, adaptivity, generalizability, and engagement. Importantly, all of the exercises adapt to user skill and ability. Behavioral tracking built within the program is used to monitor individual performance and ensure that the person is training at their uppermost threshold level. Specifically, we will use eight BrainHQ exercises which are designed to address cognitive concerns most noted in BCS including exercises to improve attention and working memory, processing speed, and executive function.