Fluid Responsiveness Prediction During Prone Position (PROLOAD)
Acute Respiratory Distress Syndrome
About this trial
This is an interventional other trial for Acute Respiratory Distress Syndrome focused on measuring Acute respiratory distress syndrome, Fluid responsiveness, Fluid resuscitation, Cardiac output, Cardiac preload, Prone position, Continuous cardiac output monitoring
Eligibility Criteria
Inclusion Criteria: adult patient (including patient under protective measures/wardship) with ARDS as defined by the Berlin criteria in the prone position as per international guidelines with a calibrated continuous cardiac output monitoring device with a clinical indication for a fluid bolus as prescribed by the clinician in charge, and fulfilling at least 2 clinical criteria: mottles, tachycardia, hypotension, drop in cardiac output, oliguria, high arterial lactate concentration, or any other detailed criterion with no respiratory efforts Exclusion Criteria: acute cor pulmonale patient treated with veno-venous extra-corporeal membrane oxygenation hemorrhagic shock Child-Pugh C cirrhosis death expected to occur in less than 24h decision to withhold or suspend active treatments intracranial hypertension lower limb amputation obstruction of the inferior vena cava acute abdominal syndrome absence of consent to participate pregnancy patient previously enrolled in the same study lack of affiliation to a social security regimen, as per French legislation patient deprived of its liberty
Sites / Locations
- CHU Gabriel Montpied
- Hôpital de la Croix Rousse, Hospices Civils de LyonRecruiting
- CHU de Nice - l'Archet 1
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Arm 13
Arm 14
Arm 15
Arm 16
Arm 17
Arm 18
Arm 19
Arm 20
Arm 21
Arm 22
Arm 23
Arm 24
Experimental
Experimental
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Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
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Experimental
Experimental
Experimental
Experimental
Trendelenburg maneuver-EE OCC-EI OCC-Tidal volume challenge
Trendelenburg maneuver-EE OCC-Tidal volume challenge-EI OCC
Trendelenburg maneuver-Tidal volume challenge-EI OCC-EE OCC
Trendelenburg maneuver-Tidal volume challenge-EE OCC-EI OCC
Trendelenburg maneuver-EI OCC-Tidal volume challenge-EE OCC
Trendelenburg maneuver-EI OCC-EE OCC-Tidal volume challenge
EE OCC-EI OCC-Tidal volume challenge-Trendelenburg maneuver
EE OCC-EI OCC-Trendelenburg maneuver-Tidal volume challenge
EE OCC-Tidal volume challenge-Trendelenburg maneuver-EI OCC
EE OCC-Tidal volume challenge-EI OCC-Trendelenburg maneuver
EE OCC-Trendelenburg maneuver-Tidal volume challenge-EI OCC
EE OCC-Trendelenburg maneuver-EI OCC-Tidal volume challenge
EI OCC-Tidal volume challenge-EE OCC-Trendelenburg maneuver
EI OCC-Tidal volume challenge-Trendelenburg maneuver-EE OCC
EI OCC-Trendelenburg maneuver-EE OCC-Tidal volume challenge
EI OCC-Trendelenburg maneuver-Tidal volume challenge-EE OCC
EI OCC-EE OCC-Trendelenburg maneuver-Tidal volume challenge
EI OCC-EE OCC-Tidal volume challenge-Trendelenburg maneuver
Tidal volume challenge-EI OCC-EE OCC-Trendelenburg maneuver
Tidal volume challenge-EI OCC-Trendelenburg maneuver-EE OCC
Tidal volume challenge-Trendelenburg maneuver-EE OCC- EI OCC
Tidal volume challenge-Trendelenburg maneuver- EI OCC-EE OCC
Tidal volume challenge-EE OCC-Trendelenburg maneuver- EI OCC
Tidal volume challenge-EE OCC- EI OCC-Trendelenburg maneuver
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence
All enrolled patients will perform the 4 tests following a cross-over design and in a randomized sequence, separated by 1-min wash-out periods with return to hemodynamic baseline values, and concluded with the 500-ml fluid bolus. There are 24 different possibilities of sequence