Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)
Stress Reaction
About this trial
This is an interventional treatment trial for Stress Reaction
Eligibility Criteria
Inclusion Criteria: ASA I-II Patients undergoing elective abdominal surgery with anesthesia duration less than 1-2h Exclusion Criteria: It is estimated that patients with difficulty in tracheal intubation (poor head and neck mobility, history of airway surgery, history of OSAHS, nail to chin distance<6cm, Malampati grade 3 and above, mouth opening<2.5cm, obesity (BMI>30kg · m-2), etc.) Hypertension patients (clinically diagnosed as hypertension), coronary heart disease patients (with typical symptoms of angina pectoris and exclusion of aortic valve disease, clear history of old myocardial infarction, clear history of acute myocardial infarction) Patients with diabetes and central nervous system diseases Patients with long-term use of sedatives or antidepressants Patients with a history of alcoholism or drug dependence Asthma or reactive airway disease Shock, severe hypotension, severe arrhythmia and other adverse events occurred during the operation
Sites / Locations
- Second of Shanxi Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Lidocaine
Control group
Lidocaine will be injected intravenously at 1.5mg/kg during anesthesia induction and intravenously pumped at 1.5mg/kg/h during anesthesia induction.
Normal saline will be injected intravenously at 1.5mg/kg during the induction period and intravenously pumped at 1.5mg/kg/h during the induction period.