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The Impact of a Race-Based Stress Reduction Intervention

Primary Purpose

Racism, Stress, Inflammation

Status
Recruiting
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
RiSE
HEP
Sponsored by
Loyola University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Racism

Eligibility Criteria

50 Years - 70 Years (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria: Between the ages of 50 and 70 Female Post-menopausal (without menstrual period for at least 12 consecutive months) Self-identified AA or Black Able to write, read, speak English Must have at least 1 of any of the following: Waist circumference >88 cm Systolic BP>130 mmHg and/ or diastolic BP>88 mmHg or on antihypertensive medications Diagnosed and/or being treated for hypercholesterolemia History of Type 2 diabetes Exclusion Criteria: History of myocardial infarction or ischemic heart disease/angina, stent placement, coronary artery bypass, left ventricular hypertrophy, congestive heart failure, or ischemic stroke Any major immune-related disease (e.g., rheumatoid arthritis. lupus) Use of immune-altering medications, such as glucocorticoids Periodontal disease, bleeding gums, dental work in past 72 hours Current smoker or has smoked in past 3 months Active cancer Active infection Substance abuse Cognitive or psychiatric disorder that would affect ability to participate in classes (Brief Screen for Cognitive Impairment total score of 8 or higher)

Sites / Locations

  • Loyola University ChicagoRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

RiSE

HEP

Arm Description

Resilience, Stress, and Ethnicity (RiSE) program is an 8-session weekly group-based intervention that integrates cognitive-behavioral strategies focused on the biopsychosocial impact of racism, racial identity development, and empowerment. RiSE has three primary components: processing and sharing experiences related to race based stress, psychoeducation on the biopsychosocial impact of racism, skill building and empowerment.

Health Education Program

Outcomes

Primary Outcome Measures

Current perceived stress
Perceived Stress Scale (PSS-10). Scores range from 0 to 40 with higher score suggesting worse outcome.
Stress overload
Stress Overload Scale. Scores range from 30 to 150 with higher score suggesting worse outcome.
Depressive symptoms
Beck Depression Inventory (BDI). Scores range from 0 to 63 with higher score suggesting worse outcome.
Anxiety
Generalized Anxiety Disorder-7 (GAD-7). Scores range from 0 to 21 with higher score suggesting worse outcome.
Fatigue
NIH Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form 8a
Sleep disturbance
NIH PROMIS Short Form v1.0
Inflammatory burden- C-reactive protein (CRP)
Salivary CRP
Inflammatory burden - Tumor necrosis factor-alpha (TNF-alpha)
Salivary TNF-alpha
Inflammatory burden - Interleukin-6 (IL-6)
Salivary IL-6
Inflammatory burden - Interleukin-1 beta (IL-1B)
Salivary IL-1B
Inflammatory burden - Interferon gamma (IFN-γ),
Salivary IFN-y

Secondary Outcome Measures

General coping
Ways of Coping Questionnaire. Scores range for 0 to 198 for total scale with higher scores suggesting more coping.
Coping with discrimination
Coping with Discrimination Scale. Scores range from 25 to 150 with higher scores suggesting more coping.
Internalized racism
Appropriated Racial Oppression Scale. Scores range from 24 to 168 with higher score suggesting worse outcome.
Resistance and empowerment
Resistance and Empowerment Against Racism Scale. Scores range from 26 to 130 with higher score suggesting better outcome.
DNA methylation
Targeted DNA methylation of targeted candidate genes

Full Information

First Posted
May 2, 2023
Last Updated
July 12, 2023
Sponsor
Loyola University
Collaborators
Columbia University
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1. Study Identification

Unique Protocol Identification Number
NCT05902741
Brief Title
The Impact of a Race-Based Stress Reduction Intervention
Official Title
The Impact of a Race-Based Stress Reduction Intervention on Well-Being, Inflammation, and DNA Methylation in African American Women at Risk for Cardiometabolic Disease
Study Type
Interventional

2. Study Status

Record Verification Date
July 2023
Overall Recruitment Status
Recruiting
Study Start Date
March 10, 2023 (Actual)
Primary Completion Date
March 2028 (Anticipated)
Study Completion Date
March 2029 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Loyola University
Collaborators
Columbia University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The goal of this clinical trial is to learn whether a stress reduction program called Resilience, Stress, and Ethnicity (RiSE) improves well-being, inflammation, and the epigenome in African American (AA) women who have risk factors for heart or metabolic disease. The main question it aims to answer is whether an intervention that integrates cognitive-behavioral strategies focused on the impact that social stress, such as racism, has on the body, racial identity development, and empowerment. Participants will placed in one of the two following groups: The RiSE program will focus on teaching participants how to reduce their stress levels and will meet online weekly for approximately 2 hours each week for 8 consecutive weeks. The Health Education program will include education on how to improve general health and will meet online weekly for approximately 2 hours each week for 8 consecutive weeks. Participants will provide saliva to measure cytokines and DNA methylation (DNAm), complete questionnaires, and have blood pressure, heart rate, and weight measured at the following clinic visits: Prior to starting the intervention Mid-way through the intervention (Week 4) End of the intervention (Week 8) Six (6) months after the completion of the intervention
Detailed Description
Participants of both programs - RiSE and Health Education Program (HEP) - will meet weekly for 8 consecutive weeks for approximately 2 hours every week. Two booster sessions will occur one month and two months after completion of the interventions. Classes will meet synchronously over Zoom. RiSE classes will be facilitated by two trained clinical psychologists. Expert speakers will be hired to provide the HEP classes (e.g dietician, pharmacist). The investigators will vary the time of day for each 8- week program in order to meet the scheduling needs of participants. Cohorts of 9-12 participants each and sessions for the treatment and control group will be provided concurrently. Topics for the health education program (HEP) (attention-control) were selected so they would not confound the overall objectives of the RiSE program.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Racism, Stress, Inflammation

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Self-identified African American women will be randomized to either the race-based stress reduction intervention group (Resilience, Stress, and Ethnicity [RiSE]) or the HEP.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
300 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
RiSE
Arm Type
Experimental
Arm Description
Resilience, Stress, and Ethnicity (RiSE) program is an 8-session weekly group-based intervention that integrates cognitive-behavioral strategies focused on the biopsychosocial impact of racism, racial identity development, and empowerment. RiSE has three primary components: processing and sharing experiences related to race based stress, psychoeducation on the biopsychosocial impact of racism, skill building and empowerment.
Arm Title
HEP
Arm Type
Active Comparator
Arm Description
Health Education Program
Intervention Type
Behavioral
Intervention Name(s)
RiSE
Intervention Description
RiSE provides participants with a platform to share the emotional impact of race-based stress and to offer supportive listening to their peers. Participants explicitly discuss the experiences they have as African American women, taking into account the ways which the interaction between their racial and gender identities shapes their experiences. Facilitators review difficulties associated with addressing racism and unique experiences of Black women at interpersonal and structural levels, and provide evidence of strategies to promote effective communication and internal emotional regulation regarding experiences of racism. Facilitators provide psychoeducation on intersectionality, structural racism, overt racism, microaggressions, and internalized racism. Following this education, facilitators help participants utilize cognitive-behavioral strategies to understand consequent thoughts, feelings, and actions associated with such experiences.
Intervention Type
Behavioral
Intervention Name(s)
HEP
Intervention Description
The HEP group will consist of classes focusing on wellness promotion. Expert speakers provide the HEP classes (e.g dietician, pharmacist).
Primary Outcome Measure Information:
Title
Current perceived stress
Description
Perceived Stress Scale (PSS-10). Scores range from 0 to 40 with higher score suggesting worse outcome.
Time Frame
8 months
Title
Stress overload
Description
Stress Overload Scale. Scores range from 30 to 150 with higher score suggesting worse outcome.
Time Frame
8 months
Title
Depressive symptoms
Description
Beck Depression Inventory (BDI). Scores range from 0 to 63 with higher score suggesting worse outcome.
Time Frame
8 months
Title
Anxiety
Description
Generalized Anxiety Disorder-7 (GAD-7). Scores range from 0 to 21 with higher score suggesting worse outcome.
Time Frame
8 months
Title
Fatigue
Description
NIH Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form 8a
Time Frame
8 months
Title
Sleep disturbance
Description
NIH PROMIS Short Form v1.0
Time Frame
8 months
Title
Inflammatory burden- C-reactive protein (CRP)
Description
Salivary CRP
Time Frame
8 months
Title
Inflammatory burden - Tumor necrosis factor-alpha (TNF-alpha)
Description
Salivary TNF-alpha
Time Frame
8 months
Title
Inflammatory burden - Interleukin-6 (IL-6)
Description
Salivary IL-6
Time Frame
8 months
Title
Inflammatory burden - Interleukin-1 beta (IL-1B)
Description
Salivary IL-1B
Time Frame
8 months
Title
Inflammatory burden - Interferon gamma (IFN-γ),
Description
Salivary IFN-y
Time Frame
8 months
Secondary Outcome Measure Information:
Title
General coping
Description
Ways of Coping Questionnaire. Scores range for 0 to 198 for total scale with higher scores suggesting more coping.
Time Frame
8 months
Title
Coping with discrimination
Description
Coping with Discrimination Scale. Scores range from 25 to 150 with higher scores suggesting more coping.
Time Frame
8 months
Title
Internalized racism
Description
Appropriated Racial Oppression Scale. Scores range from 24 to 168 with higher score suggesting worse outcome.
Time Frame
8 months
Title
Resistance and empowerment
Description
Resistance and Empowerment Against Racism Scale. Scores range from 26 to 130 with higher score suggesting better outcome.
Time Frame
8 months
Title
DNA methylation
Description
Targeted DNA methylation of targeted candidate genes
Time Frame
8 months

10. Eligibility

Sex
Female
Gender Based
Yes
Gender Eligibility Description
Self-identified African American women
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Between the ages of 50 and 70 Female Post-menopausal (without menstrual period for at least 12 consecutive months) Self-identified AA or Black Able to write, read, speak English Must have at least 1 of any of the following: Waist circumference >88 cm Systolic BP>130 mmHg and/ or diastolic BP>88 mmHg or on antihypertensive medications Diagnosed and/or being treated for hypercholesterolemia History of Type 2 diabetes Exclusion Criteria: History of myocardial infarction or ischemic heart disease/angina, stent placement, coronary artery bypass, left ventricular hypertrophy, congestive heart failure, or ischemic stroke Any major immune-related disease (e.g., rheumatoid arthritis. lupus) Use of immune-altering medications, such as glucocorticoids Periodontal disease, bleeding gums, dental work in past 72 hours Current smoker or has smoked in past 3 months Active cancer Active infection Substance abuse Cognitive or psychiatric disorder that would affect ability to participate in classes (Brief Screen for Cognitive Impairment total score of 8 or higher)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Karen Saban, RN, PhD
Phone
708-216-1244
Email
ksaban@luc.edu
First Name & Middle Initial & Last Name or Official Title & Degree
Susan Fargo
Phone
708-216-8046
Email
sfargo@luc.edu
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Karen Saban, RN, PhD
Organizational Affiliation
Loyola University Chicago
Official's Role
Principal Investigator
Facility Information:
Facility Name
Loyola University Chicago
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karen Saban, RN, PhD
Phone
708-216-1244
Email
ksaban@luc.edu
First Name & Middle Initial & Last Name & Degree
Karen Saban, RN, PhD

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
Genomic data will be individual level data. Analysis of genomic DNA will link genotype to phenotypic information obtained as part of this study. Genomic data will include Genome wide association (GWAS) and DNA methylation (EWAS). Genomic data will be obtained from saliva taken at baseline, at completion of intervention, and 6 months after completion of intervention. The protocol, sample informed consent, case report forms, data dictionary, and code book will be made accessible in data repositories where data are shared. For data submitted to Database of Genotypes and Phenotypes (dbGaP), variable-level metadata will be provided using details of Common Data Elements, definitions, and standards used for data collection and sharing.
IPD Sharing Time Frame
The repository will make the data accessible within 3 years of last participant study visit or at the end of the performance period, or no later than the date of online publication, whichever is soon. Genomic data will be shared according to Genomic Data Sharing (GDS) policy, which requires that genomic data must be submitted within 3 months following data generation, and released within 6 months of data submission to the repository or at acceptance of the publication, whichever is first. Data will be preserved within the repository for at least three years following the completion of the grant, as required by federal retention guidelines.
IPD Sharing Access Criteria
Data will be shared with controlled access in the dbGAP for non-commercial research use by qualified investigators, as allowed by the participants' informed consent and the Institutional Certification. Due to ethical considerations, access to the resulting scientific data will be limited and approved by the Multiple Principal Investigators (MPI) Saban and Taylor.

Learn more about this trial

The Impact of a Race-Based Stress Reduction Intervention

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