Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)
Infertility, Male
About this trial
This is an interventional treatment trial for Infertility, Male focused on measuring Spinal cord injury
Eligibility Criteria
Inclusion Criteria: Subject has a traumatic spinal cord injury. Subject is male and is 18 years or older. Exclusion Criteria: Subject has been injured less than 1 year. The subject is known to be azoospermic. The subject has an indwelling urethral Foley catheter. Subject is under the age of 18 years. Subject has an unstable medical condition including, but not limited to, Crohn's disease, ulcerative colitis, colon cancer or has other conditions deemed to be exclusionary per the Investigator. Subject is unable to consent or comprehend the procedures and their implications. Subject has a permanent implanted electrical device, i.e., cardiac pacemaker, phrenic nerve stimulator, spinal cord stimulator, etc. Any subject for whom the procedure or medication is otherwise contraindicated. Subject has hypersensitivity to probenecid. Subject has a history of uric acid kidney stones and/or peptic ulcer. The subject has had a febrile Urinary Tract Infection (UTI) within the 2 months prior to enrollment. The subject is taking methotrexate, aspirin, other salicylates, or anti-inflammatory medicines. The subject has a history of Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Sites / Locations
- University of Miami
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
Full dose group
Half dose group
Control-placebo group
Participants in this group will receive the full dose of probenecid for a total of 90 days.
Participants in this group will receive half the dose of probenecid for a total of 90 days.
Participants in this group will receive a placebo dose (No active ingredient) for a total of 90 days.