Symptom-inhibited Fentanyl Induction (SIFI)
Opioid Use Disorder
About this trial
This is an interventional treatment trial for Opioid Use Disorder focused on measuring Fentanyl, Methadone, Morphine, Opioid agonist therapy
Eligibility Criteria
Inclusion Criteria: Opioid use disorder (OUD) of any severity by DSM-5 Clinical Diagnostic criteria Intentional use of unregulated fentanyl by any route (injection and/or inhalation) by participant self-report Urine drug test (UDT) positive for fentanyl at screening or within 7 days prior to date of screening visit Clinical indication to start OAT with methadone or SROM Willing and able to provide written informed consent for study participation Exclusion Criteria: Individuals who are pregnant or breast-feeding Currently receiving prescribed fentanyl in any form, e.g. fentanyl patch Previous participation in this study
Sites / Locations
Arms of the Study
Arm 1
Experimental
Symptom-inhibited IV fentanyl induction
Symptom-inhibited IV fentanyl induction followed by opioid agonist therapy (OAT) with either oral methadone or slow-release oral morphine (SROM)