Autologous T-cells Transfected With mRNA Encoding HBV-TCR T Cell Therapy in Combination With NUC for Chronic Hepatitis B

Inclusion Criteria: HBsAg Positive, HBeAg Negative, Anti-HBe Positive (with HBeAg seroconversion). On first-line treatment with oral nucleoside analogs antiviral drug therapy for more than a year. Adequate organ function Willing to stop and/or not to be on other immunomodulators during the study period, and to inform in time when other treatments such as glucocorticoids are needed Liver biopsy, Fibroscan® or equivalent test obtained within the past 6 months demonstrating liver disease consistent with chronic HBV infection without evidence of bridging fibrosis or cirrhosis (≥ Metavir 3, recommended cut-off for Fibroscan 9.0kPa) Females of childbearing potential must have a negative pregnancy test at Screening (within 3 days prior to first dose) and be willing to have additional pregnancy tests during the study. Females considered not of childbearing potential include those who have been in menopause at least 2 years, or had tubal ligation at least 1 year prior to Screening, or who have had total hysterectomy. Willing and able to comply with all study procedures. Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures. Exclusion Criteria: History of Acute infection, gastrointestinal bleeding, etc. occurring within 28 days prior to study enrollment. Advanced liver cirrhosis, Child-Pugh score ≥ 7 or clinical symptoms of liver function decompensation such as ascites and varicose veins Positive test for other viral infections, anti-HAV IgM, anti HCV, anti-HDV, anti -HEV and anti-HIV Any item is positive; liver disease caused by other reasons (such as autoimmune liver disease, alcoholic liver disease, non-alcoholic liver disease, drug-induced liver disease and other liver diseases of unknown cause, etc.). History of or suspicion of hepatocellular carcinoma or alpha fetoprotein (AFP) > 20 ng/mL at Screening. If AFP > 20 ng/mL, hepatic imaging must exclude hepatocellular carcinoma. History of having received (in the last 6 months) or currently receiving any other cell therapies History of organ transplantation History of severe allergic reaction (hives or anaphylaxis) to blood products History of any Grade 4 immune-related AE from prior immunotherapy. Any immune-related AE that led to permanent discontinuation that occurred less than 6 months prior to leukapheresis or whole blood collection for production Use of any investigational product (IP) within 28 days of study treatment administration. Lack of peripheral venous or central venous access or any condition that would interfere with drug administration or collection of study samples