Dose Response Relationship Between Fat Ingestion and Metabolism (AFDR)
Glucose Tolerance Impaired
About this trial
This is an interventional basic science trial for Glucose Tolerance Impaired focused on measuring High-fat, Glucose, Insulin, Metabolism, Nutrition
Eligibility Criteria
Inclusion Criteria: BMI between 18.5 and 30.0 kg/m2 Weight stable for the past 6 months (± 2kg) VO2max values within a below average to above average range (38-50 mL/kg and 35-47 mL/kg for 18-25 year old males and females respectively. 35-48 mL/kg and 34-45 mL/kg for 26-35 year old males and females respectively) Fasting blood glucose <6.0 mM Resting blood pressure <140/90 mmHg Taking second generation oral contraceptives (females only) Exclusion Criteria: Smoking Diabetes, cancer, or other metabolic disorders Cardiac or gastrointestinal problems Infectious disease Barium swallow or nuclear medicine scan in the previous 3 weeks Follow a strict vegan diet Pregnant or breastfeeding (females only) Diagnosis of polycystic ovary syndrome (females only)
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
20% fat meal
40% fat meal
60% fat meal
80% fat meal
This meal will contain 15 kcal/kg of body weight and consist of 20% fat, 65% carbohydrates, and 15% protein.
This meal will contain 15 kcal/kg of body weight and consist of 40% fat, 45% carbohydrates, and 15% protein.
This meal will contain 15 kcal/kg of body weight and consist of 60% fat, 25% carbohydrates, and 15% protein.
This meal will contain 15 kcal/kg of body weight and consist of 80% fat, 5% carbohydrates, and 15% protein.