Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-1b) (PROTECT)
Acute Ischemic Stroke, Reperfusion Injury
About this trial
This is an interventional treatment trial for Acute Ischemic Stroke
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years; Acute ischemic stroke within 24 hours from stroke onset (or from time last known well) to groin puncture; Previous mRS ≤ 2; Baseline NIHSS ≥ 6; Baseline ASPECTS ≥ 6; With an occlusion of unilateral middle cerebral artery M1 segment/distal intracranial carotid artery; Successful recanalization (mTICI ≥ 2b) after thrombectomy confirmed by DSA; Written informed consent provided by the patients or their legal relatives. Exclusion Criteria: Confirmed or clinically suspected cerebral vasculitis/fibromuscular dysplasia; Difficulty in reaching the designated position of the balloon used for ischemic post-conditioning; Stenting in the middle cerebral artery M1 segment/distal intracranial carotid artery during thrombectomy; > 2 times balloon dilations as rescue therapy due to angioplasty during thrombectomy; Moderate/severe residual stenosis (≥ 50%) in the offending artery after thrombectomy; Patients with contraindications to MRI; Other conditions that the investigator considered inappropriate for inclusion.
Sites / Locations
- Tianjin Huanhu HospitalRecruiting
Arms of the Study
Arm 1
Experimental
Ischemic post-conditioning group
Mechanical thrombectomy combined with ischemic post-conditioning