LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy (LEAP-CAR)
Bradycardia, Heart Failure, Pacemaker-Induced Cardiomyopathy
About this trial
This is an interventional prevention trial for Bradycardia focused on measuring left bundle branch area pacing, conduction system pacing, physiologic pacing, pacing-induced cardiomyopathy
Eligibility Criteria
Inclusion Criteria: advanced AVB (frequent 2° degree or 3° degree AVB, atrial fibrillation - AF - with advanced AV block) and preserved or slightly reduced LVEF (>45%) Exclusion Criteria: LVEF ≤45% signs or symptoms of heart failure at enrollment unstable angina or acute coronary syndrome <3 months percutaneous coronary intervention or coronary-artery bypass surgery <3 months life expectancy <6 months previous hospitalization for heart failure evidence of pulmonary artery hypertension of any origin valvular disease greater than moderate previous heart transplant pregnancy
Sites / Locations
- Hospital "Maggiore della Carità", Division of CardiologyRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Left bundle branch area pacing (LBBAP)
Right ventricular pacing (RVP)
Implant of the ventricular lead of the pacemaker in the left bundle branch area
Implant of the ventricular lead of the pacemaker in a conventional site for pacing (apex/paraapical interventricular septum)