Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism (HEPACORT)
Cushing Syndrome, Metabolic Syndrome
About this trial
This is an interventional diagnostic trial for Cushing Syndrome
Eligibility Criteria
Inclusion Criteria: age ≥ 18 years old; Person affiliated to a social security scheme or beneficiary of such a scheme; Person having received complete information on the organization of the research and having signed informed consent; Person having carried out a preliminary clinical examination adapted to the research. Patients with Cushing's syndrome (for the Cushing's Syndrome group) Patients with possible Cushing's syndrome (for the suspected Cushing's Syndrome group) defined as response to the dexamethasone supression test with 1 mg of Dexamethasone, with a plasma cortisol assay at 8 am between 18 and 50 µg/L carried out in the 3 months preceding ; Patients with metabolic syndrome (for the metabolic syndrome group) Exclusion Criteria: Person having taken corticosteroid therapy for more than 3 months during the 2 years preceding inclusion; Person having received corticosteroid therapy of shorter duration with discontinuation less than one month before inclusion; Person having taken anticortisolic treatment for more than 3 months during the 2 years preceding inclusion; Person with chronic liver disease; Person with alcohol misuse, defined by a weekly consumption of more than 10 standard units; Person with a morphotype that does not allow an MRI examination to be performed; Woman of childbearing age who does not have an effective means of contraception; Contraindication to performing an MRI examination. Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the French Public Health Code.
Sites / Locations
- CHRU NancyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Cushing's Syndrome
Suspected Cushing's Syndrome
Metabolic Syndrome
Patients with proven autonomic cortisol secretion (Cushing's Syndrome)
Patients with possible autonomic cortisol secretion (Suspected Cushing's Syndrome)
Patients with metabolic syndrome