Exercise to Augment TMS in Those With Treatment Resistant Depression
Treatment Resistant Depression
About this trial
This is an interventional treatment trial for Treatment Resistant Depression focused on measuring Aerobic Exercise, Transcranial Magnetic Stimulation
Eligibility Criteria
Inclusion Criteria: adult outpatients (age 18 and above) who are already approved to receive standard TMS therapy through the Butler Hospital TMS clinic. able to safely engage in moderate-intensity aerobic exercise (determined by a study physician) Exclusion Criteria: Currently pregnant or plans to become pregnant in the next 6 weeks
Sites / Locations
- Butler Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Aerobic Exercise
Video Condition
Exercise sessions will be 20 minutes of moderate-intensity aerobic exercise on a treadmill. A treadmill is located on D1A within the space shared by the Butler Hospital TMS Clinic and the COBRE-support Neuromodulation Research Facility. A research staff member will monitor their heart rate and blood pressure to ensure safety and that activity is occurring at a moderate intensity (i.e., 64-76% of age predicted maximal heart rate). Participants will be asked to rate their affect and rating of perceived exertion (RPE) during exercise sessions. Sessions will include a 5-min warm-up and a 5-min cool-down to ensure safe exercise procedures. Participants will be asked to answer questions about affect before, during, and after exercise. These sessions will be supervised (i.e., they provide onsite coverage) by an exercise physiologist or medical staff member (e.g., nurse or physician) to ensure safety.
In this condition, participants will be asked to sit and watch various documentaries or educational videos on topics NOT related to physical activity. These will last approximately 20 minutes and will occur before each TMS session.