Effects of High-frequency Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Cerebral Small Vessel Disease

Inclusion Criteria: Age 18-80 years, regardless of gender; Diagnosed with CSVD, and neuroimaging presented as recent small subcortical infarcts; Initiated transcranial magnetic stimulation within 7 days of onset; Subject or legal representative agreed to the treatment and signed the informed consent; Exclusion Criteria: Vascular stenosis > 50% diagnosed by Transcranial Doppler (TCD) and carotid ultrasound; Previous history of atrial fibrillation or myocardial infarction within 6 months; Moyamoya disease or hereditary cerebral small vessel disease, such as CADASIL; White matter hyperintensities (WMH) of non-vascular origin; Severe hepatic and renal diseases, cancer or other major diseases related to integral medical and surgical procedures; Patients with contraindications to transcranial magnetic stimulation, such as metal or electronic devices in the brain; Pregnant or breastfeeding women; The patients with disorders of consciousness, agitation or insufficient bilateral temporal bone windows for insonation who cannot cooperate to dynamic cerebral autoregulation monitoring; Previous history of epilepsy or family history of epilepsy; Previous treatment with transcranial magnetic stimulation or its equivalent; Unwillingness to be followed up or poor adherence to treatment; Those who are participating in other clinical investigators, or who have participated in other clinical studies within 3 months prior to enrollment, or who have participated in this study; Other conditions that the investigators deemed unsuitable for enrollment.