Effects of Polyphenols of Pomegranate Fruit Peel Extract on Inflammation and Oxidative Stress in Metabolic Syndrome
Metabolic Syndrome
About this trial
This is an interventional treatment trial for Metabolic Syndrome focused on measuring Metabolic syndrome, Inflamation, Oxidative stress, Obesity, Polyphenols of Pomegranate Fruit Peel Extract
Eligibility Criteria
Inclusion Criteria: Informed consent signed Adults of 20 to 60 years BMI ≥ 25.00 kg/m2 Met criteria for metabolic syndrome such as visceral obesity( for men ≥ 94 cm and ≥ 80 cm for women) and at least two risk factors: TG ≥ 1,7 mmol/l, or present therapy for dyslipidemia HDL <1,03 mmol/l men, <1,29 mmol/l women Arterial blood pressure ≥130/85 mmHg Glycemia ≥ 5.6 mmol/l and < 6.9 mmol/l Exclusion Criteria: Subjects with malignant and other acute and chronic infectious and non-infectious disease requiring active pharmacotherapy. Subjects with with insulin dependent diabetes mellitus or subjects with insulin independent diabetes mellitus taking oral hypoglycemic therapy Subjects with uncontrolled chronic cardiovascular, endocrine, autoimmune, psychiatric, and autoimmune diseases or other condition based on the investigator judgement. Non adherent subject Systematic use of corticosteroids Pregnant or lactating women Chronic use of supplements (omega 3 unsaturated acids, silymarin, mineral-vitamin supplements) Participation in any other interventional study
Sites / Locations
- Public Health Institution Dom zdravlja Banja Luka
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Polyphenols of pomegranate fruit peel extract (PoPex)
Placebo
All subjects will treated only with PoPex in total daily dosis of 500 mg/orally over 8 weeks.
All subjects will treated only with PoPex placebo capsules/orally over 8 weeks